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Art. -Nr.: HY-119238

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CRL-42872

CRL-42872 is an orally active, highly bioavailable Gp IIb/IIIa platelet receptor inhibitor. CRL-42872 inhibits the binding of fibrinogen to the Gp IIb/IIIa receptor, thereby suppressing collagen-induced platelet aggregation. CRL-42872 is widely used in thrombosis-related studies.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 256385-24-7
Formel: C₂₂H₂₇ClN₆O₆S
Molecular Weight:539.00

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

CRL-42872 Chemical Structure

CAS. Nr.: 256385-24-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

CRL-42872 (1.5×10^-8 M - 7×10^-5 M; 3 minutes) potently inhibits collagen-induced aggregation of guinea pig platelets with an IC₅₀ of 9.4×10^-8 M^[1].
CRL-42872 (10^-8 M - 5×10^-5 M; 3 minutes) inhibits collagen-induced aggregation of human platelets with an IC₅₀ of 1.2×10^-7 M^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CRL-42872 (10 mg/kg; p.o.; single dose) achieves inhibition of collagen-induced guinea pig platelet aggregation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Dunkin-Hartley (male, ~330 g)^[1]
Dosage:

10 mg/kg
Administration:

p.o.; single dose
Result:

Inhibited collagen-induced platelet aggregation by 68% at 1 hour post-administration.
Inhibited collagen-induced platelet aggregation by 64% at 2 hours post-administration.

Chemical Information

CAS. Nr. 256385-24-7
Molecular Weight 539.00
Formel C₂₂H₂₇ClN₆O₆S
SMILES

O=C1CN(C2=CC=C(C=C2)C(N)=N)CCN1CC(NC[C@@H](C(O)=O)NS(=O)(C3=CC=CC=C3)=O)=O.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yue C, et al. Substituted piperazinones and their therapeutic uses: U.S. Patent 6,335,337[P]. 2002-1-1.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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