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Art. -Nr.: HY-185107

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CTR/AMYR modulator-2

CTR/AMYR modulator-2 is a dual agonist of human amylin receptor 3 (AMY3R) and calcitonin receptor (CTR). CTR/AMYR modulator-2 activates AMY3R and CTR, stimulating Rel EC₅₀ of cAMP production in UMUC3 cells by 4 nM and 1 nM, respectively. CTR/AMYR modulator-2 may be used in research on type 2 diabetes and obesity.

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CAS. Nr.: 3108095-52-6
Formel: C₃₃H₃₅ClF₂N₈O₃
Molecular Weight:665.13

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CTR/AMYR modulator-2 Chemical Structure

CAS. Nr.: 3108095-52-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

AMY3R

4 nM (EC₅₀)

CTR

1 nM (EC₅₀)

In Vitro

CTR/AMYR modulator‑2 (Example 107) acts as an agonist at the human amylin receptor (AMY3R) in UMUC3 cells, with a Rel EC₅₀ of 4 nM and an Emax of 99% as determined in a 20‑point concentration‑response assay following 30 min of incubation^[1].
CTR/AMYR modulator‑2 acts as an agonist at the human calcitonin receptor (CTR) in UMUC3 cells, with a Rel EC₅₀ of 1 nM and an Emax of 88% under the same 20‑point assay conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3108095-52-6
Appearance Powder
Molecular Weight 665.13
Formel C₃₃H₃₅ClF₂N₈O₃
SMILES

O=C(C1=C(CC(C)C)N=C2C(C=NN2C3CCN(C4CC(F)(C4)F)CC3)=C1C5=CC(OCC(N6CC7=NC=C(C=N7)Cl)=O)=C6C=C5)N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Renato A. BAUER, et al. 4-phenyl-1h-pyrazolo[3,4-b]pyridine-5-carboxamide derivatives as amylin and/or calcitonin receptor agonists for the treatment of type 2 diabetes, obesity or overweight. WO2025240893A1. 2025.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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