CYY292
Based on 1 Customer Validation
CYY292 is an FGFR1 inhibitor that specifically targets the FGFR1/AKT/Snail pathway in GBM cells. CYY292 dose-dependently inhibits cancer cell proliferation, epithelial-mesenchymal transition, stemness, invasion, and migration in vitro.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.19%
- CAS. Nr.: 2644673-04-9
- Formel: C24H28N8O
- Molecular Weight:444.53
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Kinase Inhibitor Library
HY-L009
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Protein Tyrosine Kinase Compound Library
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Biologische Aktivität
FGFR1[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HOS-TE85 | IC50 |
1.36 μM
Compound: 7l
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Antiproliferative activity against human MNNG/HOS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MNNG/HOS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 35239349] |
| MG-63 | IC50 |
0.84 μM
Compound: 7l
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Antiproliferative activity against human MG-63 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MG-63 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 35239349] |
| SAOS-2 | IC50 |
0.72 μM
Compound: 7l
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Antiproliferative activity against human SAOS-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SAOS-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 35239349] |
| U2OS | IC50 |
0.76 μM
Compound: 7l
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Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 35239349] |
Chemical Information
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CAS. Nr. 2644673-04-9
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Appearance Solid
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Molecular Weight 444.53
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Formel C24H28N8O
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Color White to off-white
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SMILES
CN1CCN(C2=C(OC)C=C(NC3=NC(NC4=CC(NN=C5)=C5C=C4)=C(C)C=N3)C=C2)CC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CYY292 Related Classifications
HY-162153 Related Classifications
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