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Art. -Nr.: HY-113722

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DAT1

DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 107401-70-7
Formel: C₁₇H₁₅N₃O₂S
Molecular Weight:325.38

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

DAT1 Chemical Structure

CAS. Nr.: 107401-70-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	300 nM Compound: 5e	Antiproliferative activity against human CEM cells after 2 days by coulter counter method Antiproliferative activity against human CEM cells after 2 days by coulter counter method	[PMID: 19663386]
FM3A	IC₅₀	730 nM Compound: 5e	Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method	[PMID: 19663386]
HeLa	IC₅₀	230 nM Compound: 5e	Antiproliferative activity against human HeLa cells after 2 days by coulter counter method Antiproliferative activity against human HeLa cells after 2 days by coulter counter method	[PMID: 19663386]
L1210	IC₅₀	850 nM Compound: 5e	Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method	[PMID: 19663386]
MOLT-4	IC₅₀	230 nM Compound: 5e	Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method	[PMID: 19663386]

In Vitro

DAT1 shows cytotoxicity with GI₅₀ values ranging from 0.05 to 1 μM in different malignant cell lines (human tumour cells from cervix, colon and lung and mouse fibrosarcoma cells) with an average value of 0.35 μM. DAT1 blocks mitosis in the prometaphase and metaphase stages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 107401-70-7
Molecular Weight 325.38
Formel C₁₇H₁₅N₃O₂S
SMILES

O=C(C1=C(N)N=C(NC2=CC=C(C=C2)OC)S1)C3=CC=CC=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Suparna Sengupta, et al. 4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system. Br J Pharmacol. 2005 Aug;145(8):1076-83. [Content Brief]

[2]. Nisha E Thomas, et al. Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics. Mol Cancer Ther. 2014 Jan;13(1):179-89. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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