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Art. -Nr.: HY-123878

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DS79182026

DS79182026 is an inhibitor of hepcidin production. DS79182026 exhibits hepcidin lowering ability in IL-6-induced acute inflammatory mouse model.

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CAS. Nr.: 2113642-80-9
Formel: C₁₈H₁₅N₅O₃
Molecular Weight:349.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DS79182026 Chemical Structure

CAS. Nr.: 2113642-80-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

DS79182026 is an inhibitor of hepcidin production. DS79182026 exhibits hepcidin lowering ability in IL-6-induced acute inflammatory mouse model^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	0.039 μM Compound: 38	Inhibition of human recombinant BMP6-stimulated hepcidin mRNA expression in human HepG2 cells after 6 hrs by qRT-PCR analysis Inhibition of human recombinant BMP6-stimulated hepcidin mRNA expression in human HepG2 cells after 6 hrs by qRT-PCR analysis	[PMID: 28705644]

Chemical Information

CAS. Nr. 2113642-80-9
Molecular Weight 349.34
Formel C₁₈H₁₅N₅O₃
SMILES

O=C(OC)NC1=NOC2=CC(C3=C(C)NN=C3C4=NC=CC=C4)=CC=C12
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Fukuda, T., et al., (2017). Discovery of DS79182026: A potent orally active hepcidin production inhibitor. Bioorganic & medicinal chemistry letters, 27(16), 3716-3722. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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