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Art. -Nr.: HY-189875

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Dynamin IN-3

Dynamin IN-3 is an inhibitor of dynamin I. Dynamin IN-3 inhibits the GTPase activity of dynamin I, with an IC₅₀of 3.3 μM (based on sheep dynamin I)—and blocks clathrin-mediated endocytosis.

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Formel: C₂₇H₃₈N₄O₂
Molecular Weight:450.62

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dynamin IN-3 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

Dynamin I

3.3 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	IC50	4.3 μM	Inhibition of clathrin-mediated endocytosis in human U2OS cells assessed by transferrin uptake assay. Inhibition of clathrin-mediated endocytosis in human U2OS cells assessed by transferrin uptake assay.	42721549

In Vitro

Dynamin IN-3 (compound 97) (4.3 μM) inhibits clathrin-mediated endocytosis in U2OS cells with an IC₅₀ of 4.3 μM^[1].
Dynamin IN-3 (3-20 µM) inhibits CME in U2OS cells, with 3 and 20 µM reducing transferrin uptake and 20 µM producing near-complete loss of transferrin signal^[1].
Dynamin IN-3 (30 mM stock; 30 min) inhibits native sheep brain dynamin I GTPase with an IC₅₀ of 3.3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 450.62
Formel C₂₇H₃₈N₄O₂
SMILES

O=C(NCCCCCCCC)/C(C#N)=C/C1=CN(CCCN(C)C)C=C1C2=CC=CC(O)=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Chiew B, et al. From indole to pyrrole-based inhibitors of the large GTPase, dynamin and the in-cell inhibition of clathrin mediated endocytosis. European journal of medicinal chemistry. 2026 Sep 01;320:119258.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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