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Art. -Nr.: HY-181810

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EG36

EG36 is a selective E. coli DnaK inhibitor that inhibits DnaK ATPase activity at a concentration of 100 μM. EG36 directly binds to the nucleotide-binding domain (NBD) of E. coli DnaK by disrupting the DnaK-DnaJ interaction. EG36 can be used for research on bacterial infectious diseases.

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CAS. Nr.: 2215779-34-1
Formel: C₃₇H₄₁FN₄O₄
Molecular Weight:624.74

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Please store the product under the recommended conditions in the Certificate of Analysis.

EG36 Chemical Structure

CAS. Nr.: 2215779-34-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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Beschreibung

IC₅₀ & Target^[1]

HSP70

Alle HSP Isoform-spezifische Produkte anzeigen :

In Vitro

EG36 (50-200 μM) inhibits DnaJ-GrpE-stimulated ATPase activity of purified E. coli DnaK in a dose-dependent manner, with measurable inhibition at 50, 100, and 200 μM, and enhanced inhibition with increasing DnaJ concentrations^[1].
EG36 directly binds to the isolated nucleotide-binding domain of E. coli DnaK and inhibits its inherent ATPase activity^[1].
EG36 does not act as a general Hsp inhibitor, as it does not alter the ATPase activity or thermal stability of bacterial HtpG^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2215779-34-1
Molecular Weight 624.74
Formel C₃₇H₄₁FN₄O₄
SMILES

COC1=CC=CC=C1N2CCC(CN3CCOC4=C(CC5=CC(C(N(CC3)C)=O)=CC=C5)C=C(C=C4)C6=CN=C(C=C6)F)(CC2)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Feng ZX, et al. ProMol_Func: A Structure-Free Deep Learning Model for Virtual Screening. JACS Au. 2026 Feb 24;6(3):1495–1502.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EG36

Alle HSP Isoform-spezifische Produkte anzeigen

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EG36 Related Classifications

HY-181810 Related Classifications