EN40
Based on 1 Customer Validation
EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM
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- Reinheit: 99.33%
- CAS. Nr.: 2094547-67-6
- Formel: C13H15NO2
- Molecular Weight:217.26
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Speicherung:
4°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
IC50: 2 uM (ALDH3A1)[1]
EN40 (10-1000 μM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:10 μM; 100 μM; 1000 μM
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Incubation Time:48 hours
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Result:Inhibited A549 cells survival.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice with A549 cells[1]
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Dosage:50 mg/kg
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Administration:Intraperitoneal injection; 50mg/kg; from 14 days; once per day
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Result:Had strong anti-tumorigenic effects in tumor xenografts.
Chemical Information
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CAS. Nr. 2094547-67-6
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Appearance Oil
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Molecular Weight 217.26
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Formel C13H15NO2
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Color Light yellow to yellow
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SMILES
C=CC(N1CCC(C)=C(C2=CC=CO2)C1)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Lösungsmittel & Löslichkeit
Ethanol : 100 mg/mL (460.28 mM; Need ultrasonic)
DMSO : ≥ 100 mg/mL (460.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| Ethanol / DMSO | 1 mM | 4.6028 mL | 23.0139 mL | 46.0278 mL | 115.0695 mL |
| 5 mM | 0.9206 mL | 4.6028 mL | 9.2056 mL | 23.0139 mL | |
| 10 mM | 0.4603 mL | 2.3014 mL | 4.6028 mL | 11.5070 mL | |
| 15 mM | 0.3069 mL | 1.5343 mL | 3.0685 mL | 7.6713 mL | |
| 20 mM | 0.2301 mL | 1.1507 mL | 2.3014 mL | 5.7535 mL | |
| 25 mM | 0.1841 mL | 0.9206 mL | 1.8411 mL | 4.6028 mL | |
| 30 mM | 0.1534 mL | 0.7671 mL | 1.5343 mL | 3.8357 mL | |
| 40 mM | 0.1151 mL | 0.5753 mL | 1.1507 mL | 2.8767 mL | |
| 50 mM | 0.0921 mL | 0.4603 mL | 0.9206 mL | 2.3014 mL | |
| 60 mM | 0.0767 mL | 0.3836 mL | 0.7671 mL | 1.9178 mL | |
| 80 mM | 0.0575 mL | 0.2877 mL | 0.5753 mL | 1.4384 mL | |
| 100 mM | 0.0460 mL | 0.2301 mL | 0.4603 mL | 1.1507 mL |
EN40 Related Classifications
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