Endosidin-2
Based on 3 publication(s) in Google Scholar
Endosidin-2 (ES2) is a selective inhibitor targeting the conserved exosome subunit EXO70. Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters (such as PIN2) in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure (such as cup-shaped or ring-shaped vesicles cisternae formation). Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking (such as polar growth, vesicle sorting).
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- Reinheit: 99.17%
- CAS. Nr.: 1839524-44-5
- Formel: C15H12FIN2O3
- Molecular Weight:414.17
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Endosidin-2
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Biologische Aktivität
1. Arabidopsis root epidermal cell PIN2 protein localization experiment: Endosidin-2 (40 μM; 2 h) significantly reduced the PIN2-GFP fluorescence intensity on the plasma membrane, induced PIN2 to accumulate in the ARA7/RabF2b-marked late endosome/pre-vacuolar compartment, inhibited exocytosis and enhanced vacuolar transport.[1].
2. Arabidopsis root epidermal cell multi-protein tracing experiment: Endosidin-2 (50 μM; 1.5-3 h) can cause PIN2, PIN3, and PIN4 to form abnormal aggregates (ES2As) in the cytoplasm, accelerate PIN2 endocytosis and redirect it to the vacuole, without affecting the localization of SYT1 protein, causing the Golgi apparatus to appear cup-shaped or ring-shaped cisternae and other structural abnormalities[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1839524-44-5
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Appearance Solid
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Molecular Weight 414.17
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Formel C15H12FIN2O3
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Color White to off-white
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SMILES
O=C(N/N=C/C1=CC(OC)=C(O)C(I)=C1)C2=CC=CC(F)=C2
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Synonyms
ES2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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J Clin Invest
GLUT9b- and ABCG2-mediated collecting duct urate transport uncover a vasopressin-independent mechanism of renal water reabsorption. [Abstract]2026 Jun 16:e197021. PMID: 42298327 -
Adv Sci (Weinh)
Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin-mediated Phagocytic Effects for Lung Cancer Treatment. [Abstract]2025 Sep 23:e08245. PMID: 40985476 -
bioRxiv
Inhibition of RhoA-mediated secretory autophagy in megakaryocytes mitigates myelofibrosis in mice. [Abstract]2024 Dec 5:2024.12.04.626665. PMID: 39677616
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (241.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Zhang C, et al. Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E41-50. [Content Brief]
[2]. Lešková A, et al. Endosidin 2 accelerates PIN2 endocytosis and disturbs intracellular trafficking of PIN2, PIN3, and PIN4 but not of SYT1. PLoS One. 2020 Aug 13;15(8):e0237448. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4145 mL | 12.0723 mL | 24.1447 mL | 60.3617 mL |
| 5 mM | 0.4829 mL | 2.4145 mL | 4.8289 mL | 12.0723 mL | |
| 10 mM | 0.2414 mL | 1.2072 mL | 2.4145 mL | 6.0362 mL | |
| 15 mM | 0.1610 mL | 0.8048 mL | 1.6096 mL | 4.0241 mL | |
| 20 mM | 0.1207 mL | 0.6036 mL | 1.2072 mL | 3.0181 mL | |
| 25 mM | 0.0966 mL | 0.4829 mL | 0.9658 mL | 2.4145 mL | |
| 30 mM | 0.0805 mL | 0.4024 mL | 0.8048 mL | 2.0121 mL | |
| 40 mM | 0.0604 mL | 0.3018 mL | 0.6036 mL | 1.5090 mL | |
| 50 mM | 0.0483 mL | 0.2414 mL | 0.4829 mL | 1.2072 mL | |
| 60 mM | 0.0402 mL | 0.2012 mL | 0.4024 mL | 1.0060 mL | |
| 80 mM | 0.0302 mL | 0.1509 mL | 0.3018 mL | 0.7545 mL | |
| 100 mM | 0.0241 mL | 0.1207 mL | 0.2414 mL | 0.6036 mL |
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