PALLD - palladin, cytoskeletal associated protein Gene

Also Known as MYN; PNCA1; CGI151; SIH002; CGI-151

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23022

About PALLD

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:168,497,052-168,928,441 (from NCBI)

This gene has 19 transcripts (splice variants), 223 orthologues, 9 paralogues and is associated with 2 phenotypes. Ubiquitous expression in endometrium (RPKM 88.4), prostate (RPKM 49.6) and 23 other tissues.

Summary

This gene encodes a cytoskeletal protein that is required for organizing the actin Cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic Cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

PALLD Products (8)

mRNA Protein Name
NM_001166108.2 NP_001159580.1 palladin isoform 1
NM_001166109.2 NP_001159581.1 palladin isoform 3
NM_001166110.2 NP_001159582.1 palladin isoform 4
NM_001367567.1 NP_001354496.1 palladin isoform 5
NM_001367568.1 NP_001354497.1 palladin isoform 6
NM_001367569.1 NP_001354498.1 palladin isoform 7
NM_001367570.1 NP_001354499.1 palladin isoform 8
NM_016081.4 NP_057165.3 palladin isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
11598191 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in Z disc IDA
IDA: Inferred from direct assay
16125169 GOA
located in actin filament IDA
IDA: Inferred from direct assay
11598191 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
17322171 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
17537434 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11598191 GOA
located in stress fiber IDA
IDA: Inferred from direct assay
11598191 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PALLD Protein Structure

I-set

I-set: Immunoglobulin I-set domain (271 - 361)

I-set

I-set: Immunoglobulin I-set domain (441 - 538)

I-set

I-set: Immunoglobulin I-set domain (794 - 885)

I-set

I-set: Immunoglobulin I-set domain (928 - 1018)

I-set

I-set: Immunoglobulin I-set domain (1027 - 1118)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1123 a.a.
Protein Preferred Names Protein Names

palladin

  • myoneurin

PALLD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PALLD Q8WX93 NCKIPSD Homo sapiens Q9NZQ3
Pull Down
17537434
Cross: Cross-species interaction Intra: Intraspecies interaction

PALLD Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P811030 PALLD Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P87018 Palladin Antibody (YA6711) WB Human

Related Diseases

Diseases Alias
Pancreatic Cancer 1

  • Pancreatic Cancer, Susceptibility To, 1

  • PNCA1

  • Cancer, Pancreatic, Susceptibility To, Type 1
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Myopathy, Spheroid Body

  • Spheroid Body Myopathy

  • Autosomal Dominant Spheroid Body Myopathy

  • SBM
Schindler Disease, Type I

  • Schindler Disease Type 1

  • Alpha-N-Acetylgalactosaminidase Deficiency Type 1

  • Schindler Disease Type 3

  • Alpha-N-Acetylgalactosaminidase Deficiency Type 3

  • Naga Deficiency Type 3

  • Neuroaxonal Dystrophy, Schindler Type

  • Naga Deficiency Type 1

  • Alpha-N-Acetylgalactosaminidase Deficiency, Type I

  • Naga Deficiency, Type I

  • Schindler Disease, Type Iii

  • N-Acetyl-Alpha-D-Galactosaminidase Deficiency Type Iii

  • Alpha-N-Acetylgalactosaminidase Deficiency, Type 1

  • Naga Deficiency, Type 1

  • Schindler Disease Type I

  • Schindler Disease

  • SCHIND

  • Schindler Disease, Type 3

  • Schindler Disease, Type 1
Dysplastic Nevus Syndrome

  • Familial Atypical Multiple Mole-Melanoma

  • Familial Atypical Multiple Mole Melanoma Syndrome

  • Melanoma-Pancreatic Cancer Syndrome

  • Famm Syndrome

  • B-K Mole Syndrome

  • Famm-Pc Syndrome

  • Fammm Syndrome

  • Familial Atypical Mole Syndrome

  • Familial Atypical Multiple Mole Melanoma-Pancreatic Carcinoma Syndrome

  • Familial Dysplastic Nevus Syndrome

  • Familial Atypical Multiple Mole Melanoma

  • Dysplastic Nevus

  • Familial Atypical Mole Melanoma Syndrome
Sarcoma

  • Connective And Soft Tissue Neoplasm

  • Tumor Of Soft Tissue And Skeleton

  • Sarcomas

  • Sarcoma - Category
Atrial Septal Defect 6

  • ASD6

  • Atrial Heart Septal Defect 6

  • Septal Defect, Atrial, Type 6
Myopathy, Myofibrillar, 3

  • Myotilinopathy

  • Myofibrillar Myopathy 3

  • MFM3

  • Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1a

  • Lgmd1a

  • Muscular Dystrophy, Limb-Girdle, Type 1a

  • Myopathy, Myofibrillar, Myotilin-Related

  • Muscular Dystrophy, Limb-Girdle, Type 1, Formerly

  • Lgmd1, Formerly

  • Muscular Dystrophy, Limb-Girdle, Type 1a, Formerly

  • Lgmd1a, Formerly

  • Qualitative Or Quantitative Defects Of Myotilin

  • Limb-Girdle Muscular Dystrophy Due To Myotilin Deficiency

  • Distal Myotilinopathy

  • Lgmd1

  • Limb-Girdle Muscular Dystrophy 1a

  • Mfm Myotilin-Related

  • Muscular Dystrophy, Limb-Girdle, Type 1

  • Myopathy Myofibrillar Myotylin-Related

  • Myopathy, Myofibrillar, Type 3
Myofibrillar Myopathy

  • Desmin Related Myopathy

  • Myotilinopathy

  • Myopathy, Myofibrillar

  • Alpha Beta Crystallinopathy

  • Desmin Storage Myopathy

  • Desminopathy

  • Filaminopathy

  • Protein Surplus Myopathy

  • Zaspopathy

  • Myofibrillar Myopathies

  • Myopathy, Myofibrillar, Desmin-Related

  • Myopathy, Desmin Storage

  • Mfm - [Myofibrillar Myopathy]
Hereditary Breast Ovarian Cancer Syndrome

  • Hereditary Breast And Ovarian Cancer Syndrome

  • Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

  • Breast And/Or Ovarian Cancer

  • Breast And Ovarian Cancer Syndrome

  • Hboc Syndrome

  • Hereditary Breast And Ovarian Cancer

  • Brca1- Brca2-Associated Hboc
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10004 PALLD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PALLD VGNC VGNC:44247
Mus musculus PALLD MGD MGI:1919583
Bos taurus PALLD VGNC VGNC:32557
Rattus norvegicus PALLD RGD RGD:2322545
Macaca mulatta PALLD VGNC VGNC:75636
Others PALLD NCBI