EPHA6 - EPH receptor A6 Gene

Also Known as EHK2; EK12; EPA6; EHK-2; HEK12; PRO57066

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 285220

About EPHA6

Cytogenetic location: 3q11.2 Genomic coordinates (GRCh38): 3:96,814,594-97,761,532 (from NCBI)

This gene has 9 transcripts (splice variants), 307 orthologues and 53 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EPHA6 Products (4)

mRNA Protein Name
NM_001080448.3 NP_001073917.2 ephrin type-A receptor 6 isoform a
NM_001278300.2 NP_001265229.1 ephrin type-A receptor 6 isoform c
NM_001278301.2 NP_001265230.1 ephrin type-A receptor 6 isoform d
NM_173655.4 NP_775926.1 ephrin type-A receptor 6 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
31483918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHA6 Protein Structure

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (128 - 301)

fn3

fn3: Fibronectin type III domain (427 - 518)

fn3

fn3: Fibronectin type III domain (549 - 621)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (643 - 722)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (726 - 807)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (838 - 1024)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (1059 - 1117)

  • 0
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  • 400
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  • 1000
  • 1130 a.a.
Protein Preferred Names Protein Names

ephrin type-A receptor 6

  • EPH homology kinase 2

EPHA6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
EPHA6 Q9UF33 ACVR1 Homo sapiens Q04771
Anti Tag CoIP
31483918
Intra
EPHA6 Q9UF33 EPHA2 Homo sapiens P29317
Affinity Chrom
35384245
Intra
EPHA6 Q9UF33 EPHA2 Homo sapiens P29317
BioID
35384245
Intra
EPHA6 Q9UF33 EPHB4 Homo sapiens P54760
Anti Tag CoIP
35384245
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHA6 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P79191 EphA6 Protein, Human (CHO, Fc) Q9UF33-1/AAI56734.1 (W23-V550) ≥ 90%, as determined by reducing SDS-PAGE.

EPHA6 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P85142 EphA6 Antibody (YA4834) WB, ELISA Human

Related Diseases

Diseases Alias
Cefuroxime Allergy

  • Cephuroxime Allergy

  • Zinacef Allergy
Oculoauricular Syndrome

  • OCACS

  • Schorderet-Munier-Franceschetti Syndrome

  • Microphthalmia, Microcornea, Anterior Segment Dysgenesis, Cataract, Ocular Coloboma, Retinal Pigment Epithelium Abnormalities, Rod-Cone Dystrophy, And Anomalies Of The External Ear

  • Oculoauricular Syndrome, Schorderet Type

  • Oculo-Auricular Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-146375 UniPR505 Antagonist 99.68% Unkown
HY-RS04430 EPHA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20397 Epha6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26906 Epha6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EPHA6 MGD MGI:108034
Felis catus EPHA6 VGNC VGNC:102693
Bos taurus EPHA6 VGNC VGNC:28536
Canis familiaris EPHA6 VGNC VGNC:58302
Rattus norvegicus EPHA6 RGD RGD:1304614
Macaca mulatta EPHA6 VGNC VGNC:84183
Others EPHA6 NCBI