PNMA3 - PNMA family member 3 Gene

Also Known as MA3; MA5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29944

About PNMA3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,056,470-153,060,462 (from NCBI)

This gene has 3 transcripts (splice variants), 560 orthologues and 13 paralogues. Biased expression in brain (RPKM 9.4), testis (RPKM 8.8) and 7 other tissues.

Summary

The protein encoded by this gene belongs to the paraneoplastic antigen MA (PNMA) family, which shares homology with retroviral Gag proteins. The PNMA antigens are highly expressed in the brain and also in a range of tumors associated with serious neurological phenotypes. PMID:16407312 reports the presence of a functional -1 ribosomal frameshift signal (consisting of a heptanucleotide shift motif followed 3' by a pseudoknot structure) in this gene, however, the frame-shifted product has not been characterized. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

PNMA3 Products (2)

mRNA Protein Name
NM_001282535.2 NP_001269464.1 paraneoplastic antigen Ma3 isoform 2
NM_013364.6 NP_037496.4 paraneoplastic antigen Ma3 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PNMA3 Protein Structure

PNMA

PNMA: PNMA (1 - 328)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 463 a.a.
Protein Preferred Names Protein Names

paraneoplastic antigen Ma3

  • paraneoplastic Ma antigen 3

PNMA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PNMA3 Q9UL41 RPH3AL Homo sapiens Q9UNE2
Validated Y2H
32296183
Intra
PNMA3 Q9UL41 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
PNMA3 Q9UL41 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alzheimer Disease 11

  • Ad11

  • Alzheimer'S Disease 11

  • Alzheimer Disease, Familial, 11

  • Alzheimer Disease-11

  • Alzheimer'S Disease 11, Late Onset
Melon Allergy

  • Cucumis Melo Fruit Allergy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10784 PNMA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PNMA3 VGNC VGNC:64262
Rattus norvegicus PNMA3 RGD RGD:1563752
Mus musculus PNMA3 MGD MGI:2180565
Macaca mulatta PNMA3 VGNC VGNC:76063
Others PNMA3 NCBI