PGK2 - phosphoglycerate kinase 2 Gene

Also Known as PGKB; PGKPS; HEL-S-272; dJ417L20.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5232

About PGK2

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:49,785,660-49,787,285 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues and 1 paralogue.

Summary

This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]

PGK2 Products (1)

mRNA Protein Name
NM_138733.5 NP_620061.2 phosphoglycerate kinase 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables phosphoglycerate kinase activity EXP
EXP: Inferred from Experiment
1278465 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGK2 Protein Structure

PGK

PGK: Phosphoglycerate kinase (8 - 406)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
Protein Preferred Names Protein Names

phosphoglycerate kinase 2

  • epididymis secretory protein Li 272

PGK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PGK2 P07205 PGK1 Homo sapiens P00558
Anti Tag CoIP
33961781
Intra
PGK2 P07205 PGK1 Homo sapiens P00558
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PGK2 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P75972 PGK2 Protein, Human (sf9, His) P07205 (S2-M417) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Immunodeficiency 58

  • IMD58

  • Severe Combined Immunodeficiency Due To Carmil2 Deficiency

  • Combined Immunodeficiency Due To Carmil2 Deficiency

  • Combined Immunodeficiency Due To Rltpr Deficiency
Phosphoglycerate Kinase 1 Deficiency

  • Pgk1 Deficiency

  • Glycogen Storage Disease Due To Phosphoglycerate Kinase 1 Deficiency

  • Phosphoglycerate Kinase Deficiency

  • Pgk Deficiency

  • Glycogenosis Due To Phosphoglycerate Kinase 1 Deficiency

  • Gsd Due To Phosphoglycerate Kinase 1 Deficiency

  • Deficiency Of Phosphoglycerate Kinase

  • PGK1D

  • Deficiency, Phosphoglycerate Kinase 1
Testicular Torsion

  • Spermatic Cord Torsion

  • Torsion Of Testis

  • Torsion Of Testicular Cord

  • Torsion Of Testicle

  • Torsion Of Spermatic Cord

  • Torsion Of Spermatic Cord Nos
Pelvic Varices

  • Varix Of Pelvis

  • Pelvic Varicose Vein
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10385 PGK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120656 Prostaglandin K2 / Unkown
HY-RS20794 Pgk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27308 Pgk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PGK2 VGNC VGNC:75966
Felis catus PGK2 VGNC VGNC:68815
Mus musculus PGK2 MGD MGI:97563
Rattus norvegicus PGK2 RGD RGD:1306627
Others PGK2 NCBI