CDKAL1 - CDK5 regulatory subunit associated protein 1 like 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54901

About CDKAL1

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:20,534,457-21,232,404 (from NCBI)

This gene has 4 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 1.8), endometrium (RPKM 1.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010]

CDKAL1 Products (1)

mRNA Protein Name
NM_017774.3 NP_060244.2 threonylcarbamoyladenosine tRNA methylthiotransferase

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDKAL1 Protein Structure

UPF0004

UPF0004: Uncharacterized protein family UPF0004 (65 - 145)

Radical_SAM

Radical_SAM: Radical SAM superfamily (209 - 381)

TRAM

TRAM: TRAM domain (433 - 492)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 579 a.a.
Protein Preferred Names Protein Names

threonylcarbamoyladenosine tRNA methylthiotransferase

  • tRNA-t(6)A37 methylthiotransferase

CDKAL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CDKAL1 Q5VV42 LCK Homo sapiens P06239
Y2H Array
25416956
Intra
CDKAL1 Q5VV42 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
CDKAL1 Q5VV42 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
CDKAL1 Q5VV42 WFS1 Homo sapiens O76024
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

CDKAL1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P811202 CDKAL1 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Wolfram Syndrome 1

  • WFS1

  • Didmoad

  • Wfs

  • Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

  • Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

  • Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

  • Wolfram Syndrome
Diabetes Mellitus

  • Diabetes
Type 1 Diabetes Mellitus 5

  • Diabetes Mellitus, Insulin-Dependent, 5

  • Latent Autoimmune Diabetes In Adults

  • IDDM5

  • Insulin-Dependent Diabetes Mellitus 5

  • T1D5

  • Lada

  • Type 1.5 Diabetes

  • Diabetes Mellitus, Insulin-Dependent, Type 5
Wolfram Syndrome

  • Didmoad Syndrome

  • Didmoad

  • Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

  • Wfs

  • Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

  • Didmoadud

  • Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

  • Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Adult Syndrome

  • Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome

  • Acro Dermato Ungual Lacrimal Tooth Syndrome

  • Pigment Anomaly-Ectrodactyly-Hypodontia Syndrome

  • Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome

  • Adult
Maturity-Onset Diabetes Of The Young, Type 3

  • Maturity-Onset Diabetes Of The Young Type 3

  • MODY3

  • Mody, Type Iii

  • Mody Type 3

  • Mody, Type 3

  • Maturity-Onset Diabetes Of The Young 3

  • Mody-3

  • Diabetes Of The Young, Maturity-Onset, Type 3
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02404 CDKAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21102 Cdkal1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27621 Cdkal1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CDKAL1 VGNC VGNC:39063
Macaca mulatta CDKAL1 VGNC VGNC:71066
Mus musculus CDKAL1 MGD MGI:1921765
Felis catus CDKAL1 VGNC VGNC:60707
Bos taurus CDKAL1 VGNC VGNC:27137
Rattus norvegicus CDKAL1 RGD RGD:1310246
Others CDKAL1 NCBI