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CAND1 - cullin associated and neddylation dissociated 1 Gene

Also Known as TIP120; TIP120A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55832

About CAND1

Cytogenetic location: 12q14.3-q15 Genomic coordinates (GRCh38): 12:67,269,358-67,319,953 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 22.8), testis (RPKM 22.7) and 25 other tissues.

Summary

This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub Proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin Ligase complex assembly and activity. In Mammalian Cell Culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

CAND1 Products (4)

mRNA	Protein	Name
NM_001329674.2	NP_001316603.1	cullin-associated NEDD8-dissociated protein 1 isoform 2
NM_001329675.2	NP_001316604.1	cullin-associated NEDD8-dissociated protein 1 isoform 2
NM_001329676.2	NP_001316605.1	cullin-associated NEDD8-dissociated protein 1 isoform 3
NM_018448.5	NP_060918.2	cullin-associated NEDD8-dissociated protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12504025	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in SCF complex assembly	IDA IDA: Inferred from direct assay	15537541	GOA
involved in cell differentiation	IDA IDA: Inferred from direct assay	10581176	GOA
involved in negative regulation of catalytic activity	IDA IDA: Inferred from direct assay	12609982	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	12609982	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of cullin-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	15537541	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21249194	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10581176	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	12609982	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAND1 Protein Structure

TIP120

0
200
400
600
800
1000
1230 a.a.

Protein Preferred Names	Protein Names
cullin-associated NEDD8-dissociated protein 1	TBP-interacting protein of 120 kDa A

CAND1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CAND1	Q86VP6	RPL27A	Homo sapiens	P46776	TAP	21145461
Intra	CAND1	Q86VP6	RPL27A	Homo sapiens	P46776	Crosslink	30021884
Intra	CAND1	Q86VP6	CUL1	Homo sapiens	Q13616	Anti Bait CoIP	12504026
Intra	CAND1	Q86VP6	CUL1	Homo sapiens	Q13616	X-Ray Diffraction	15537541
Intra	CAND1	Q86VP6	CUL1	Homo sapiens	Q13616	Pull Down	12504026
Intra	CAND1	Q86VP6	CUL1	Homo sapiens	Q13616	Affinity Chrom	12609982
Intra	CAND1	Q86VP6	CUL1	Homo sapiens	Q13616	CoIP	12609982
Intra	CAND1	Q86VP6	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	21145461
Intra	CAND1	Q86VP6	CUL1	Homo sapiens	Q13616	TAP	21145461
Intra	CAND1	Q86VP6	CUL4B	Homo sapiens	Q13620	Affinity Chrom	12609982
Intra	CAND1	Q86VP6	CUL4B	Homo sapiens	Q13620	CoIP	12609982
Intra	CAND1	Q86VP6	CUL4B	Homo sapiens	Q13620	TAP	21145461
Intra	CAND1	Q86VP6	CUL4B	Homo sapiens	Q13620	Pull Down	25435324
Intra	CAND1	Q86VP6	CUL4A	Homo sapiens	Q13619	Affinity Chrom	12609982
Intra	CAND1	Q86VP6	CUL3	Homo sapiens	Q13618	Affinity Chrom	12609982
Intra	CAND1	Q86VP6	CUL3	Homo sapiens	Q13618	TAP	21145461
Intra	CAND1	Q86VP6	CUL2	Homo sapiens	Q13617	Affinity Chrom	12609982
Intra	CAND1	Q86VP6	CUL2	Homo sapiens	Q13617	CoIP	12609982

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01876	CAND1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21504	Cand1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28022	Cand1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CAND1	RGD	RGD:620479
Macaca mulatta	CAND1	VGNC	VGNC:70679
Canis familiaris	CAND1	VGNC	VGNC:38694
Felis catus	CAND1	VGNC	VGNC:60344
Mus musculus	CAND1	MGD	MGI:1261820
Bos taurus	CAND1	VGNC	VGNC:26734
Others	CAND1	NCBI