RALA - RAS like proto-oncogene A Gene

Also Known as RAL; HINCONS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5898

About RALA

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:39,623,572-39,708,120 (from NCBI)

This gene has 5 transcripts (splice variants), 225 orthologues, 35 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 22.0), lung (RPKM 20.7) and 25 other tissues.

Summary

The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with Other ras proteins. [provided by RefSeq, Jul 2008]

RALA Products (1)

mRNA	Protein	Name
NM_005402.4	NP_005393.2	ras-related protein Ral-A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	24056301	GOA
enables Edg-2 lysophosphatidic acid receptor binding	IDA IDA: Inferred from direct assay	19306925	GOA
enables GDP binding	IDA IDA: Inferred from direct assay	24056301	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	24056301	GOA
enables GTPase activity	IMP IMP: Inferred from mutant phenotype	30500825	GOA
enables myosin binding	IPI IPI: Inferred from physical interaction	24056301	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7673236	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24056301	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	30500825	GOA
involved in establishment of protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	21822277	GOA
involved in membrane raft localization	IDA IDA: Inferred from direct assay	20005108	GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	34096503	GOA
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	10051605	GOA
involved in positive regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	21822277	GOA
involved in receptor internalization	IGI IGI: Inferred from genetic interaction	34096503	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	10051605	GOA
involved in regulation of exocytosis	IDA IDA: Inferred from direct assay	20005108	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cell surface	IDA IDA: Inferred from direct assay	19306925	GOA
located in cleavage furrow	IDA IDA: Inferred from direct assay	18756269	GOA
colocalizes with endocytic vesicle	IDA IDA: Inferred from direct assay	19306925	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	21822277	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17875936	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RALA Protein Structure

Ras

0
100
206 a.a.

Protein Preferred Names	Protein Names
ras-related protein Ral-A	RALA Ras like proto-oncogene A

RALA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	RALA	P11233	HRAS	Homo sapiens	P01112	Pull Down	19222999
Intra	RALA	P11233	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	17540176
Intra	RALA	P11233	RALBP1	Homo sapiens	Q15311	PLA	25241761

Cross: Cross-species interaction Intra: Intraspecies interaction

RALA Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P84055	RALA Antibody (YA3752)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P84055A	RALA Antibody (YA3752)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey

Related Diseases

Diseases	Alias
Hiatt-Neu-Cooper Neurodevelopmental Syndrome	HINCONS
Laryngeal Tuberculosis	Tuberculosis, Laryngeal
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Ras-Associated Autoimmune Leukoproliferative Disorder	RALD Autoimmune Lymphoproliferative Syndrome Type 4 Alps4 Autoimmune Lymphoproliferative Syndrome, Type Iv Ras-Associated Autoimmune Leukoproliferative Disease Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic Alps Type 4 Alps Type Iv Autoimmune Lymphoproliferative Syndrome Type Iv Autoimmune Lymphoproliferative Syndrome 4
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-12875	BQU57	Inhibitor	98.47%	Unkown
HY-12873	RBC8	Inhibitor	98.0%	Unkown
HY-125987	RBC6	Inhibitor	98.88%	Unkown
HY-175531	EGFR-IN-169		/	Unkown
HY-RS11627	RALA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20808	Rala Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27322	Rala Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RALA	VGNC	VGNC:69227
Macaca mulatta	RALA	VGNC	VGNC:108434
Bos taurus	RALA	VGNC	VGNC:33698
Canis familiaris	RALA	VGNC	VGNC:45330
Mus musculus	RALA	MGD	MGI:1927243
Rattus norvegicus	RALA	RGD	RGD:619851
Others	RALA	NCBI