RBBP5 - RB binding protein 5, histone lysine methyltransferase complex subunit Gene

Also Known as RBQ3; SWD1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5929

About RBBP5

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,086,142-205,121,978 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 6.5), lymph node (RPKM 6.0) and 25 other tissues.

Summary

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]

RBBP5 Products (3)

mRNA	Protein	Name
NM_001193272.2	NP_001180201.1	retinoblastoma-binding protein 5 isoform 2
NM_001193273.2	NP_001180202.1	retinoblastoma-binding protein 5 isoform 3
NM_005057.4	NP_005048.2	retinoblastoma-binding protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables histone binding	IDA IDA: Inferred from direct assay	15960975	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12482968	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	16603732	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	17500065	GOA
involved in response to estrogen	IDA IDA: Inferred from direct assay	16603732	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	19556245	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of MLL1 complex	IDA IDA: Inferred from direct assay	15960975	GOA
part of MLL1 complex	IPI IPI: Inferred from physical interaction	23508102	GOA
part of MLL1/2 complex	IPI IPI: Inferred from physical interaction	23508102	GOA
part of MLL3/4 complex	IDA IDA: Inferred from direct assay	17500065	GOA
part of MLL3/4 complex	IPI IPI: Inferred from physical interaction	23508102	GOA
part of Set1C/COMPASS complex	IDA IDA: Inferred from direct assay	17998332	GOA
part of Set1C/COMPASS complex	IPI IPI: Inferred from physical interaction	23508102	GOA
part of histone methyltransferase complex	IDA IDA: Inferred from direct assay	17355966	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15199122	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBBP5 Protein Structure

WD40

0
100
200
300
400
500
538 a.a.

Protein Preferred Names	Protein Names
retinoblastoma-binding protein 5	RBBP-5

RBBP5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	RBBP5	Q15291	SETD1A	Homo sapiens	O15047	Anti Tag CoIP	33961781
Intra	RBBP5	Q15291	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	16603732
Intra	RBBP5	Q15291	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	17500065
Intra	RBBP5	Q15291	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	17178841
Intra	RBBP5	Q15291	WDR5	Homo sapiens	P61964	Anti Bait CoIP	17041588
Intra	RBBP5	Q15291	WDR5	Homo sapiens	P61964	ITC	21220120
Intra	RBBP5	Q15291	WDR5	Homo sapiens	P61964	Anti Bait CoIP	17500065
Intra	RBBP5	Q15291	WDR5	Homo sapiens	P61964	Anti Bait CoIP	17178841
Intra	RBBP5	Q15291	WDR5	Homo sapiens	P61964	Anti Bait CoIP	17925232
Intra	RBBP5	Q15291	WDR5	Homo sapiens	P61964	Pull Down	17500065
Intra	RBBP5	Q15291	WDR5	Homo sapiens	P61964	Pull Down	21220120
Intra	RBBP5	Q15291	KMT2A	Homo sapiens	Q03164	Pull Down	15960975
Intra	RBBP5	Q15291	KMT2A	Homo sapiens	Q03164	Anti Tag CoIP	15960975
Intra	RBBP5	Q15291	KMT2A	Homo sapiens	Q03164	Anti Tag CoIP	33961781
Intra	RBBP5	Q15291	PAXIP1	Homo sapiens	Q6ZW49	Anti Bait CoIP	17500065
Intra	RBBP5	Q15291	PAXIP1	Homo sapiens	Q6ZW49	Anti Bait CoIP	17925232
Intra	RBBP5	Q15291	PAXIP1	Homo sapiens	Q6ZW49	Anti Bait CoIP	17178841
Intra	RBBP5	Q15291	PAXIP1	Homo sapiens	Q6ZW49	Anti Tag CoIP	33961781
Intra	RBBP5	Q15291	CXXC1	Homo sapiens	Q9P0U4	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

RBBP5 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80302	RbBP5 Antibody (YA102)	WB	Human, Mouse, Rat
HY-P85617	RbBP5 Antibody (YA5309)	WB, ICC/IF, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Kabuki Syndrome 1	Kabuki Syndrome Niikawa-Kuroki Syndrome Kabuki Make-Up Syndrome Kms KABUK1 Kabuki Make Up Syndrome Nks Kabuki Makeup Syndrome Kabuki Syndrome, Type 1
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS11717	RBBP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RBBP5	RGD	RGD:1305532
Mus musculus	RBBP5	MGD	MGI:1918367
Felis catus	RBBP5	VGNC	VGNC:69257
Macaca mulatta	RBBP5	VGNC	VGNC:76676
Canis familiaris	RBBP5	VGNC	VGNC:53127
Bos taurus	RBBP5	VGNC	VGNC:50641
Others	RBBP5	NCBI