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HSPBAP1 - HSPB1 associated protein 1 Gene

Also Known as PASS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79663

About HSPBAP1

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,739,999-122,793,831 (from NCBI)

This gene has 6 transcripts (splice variants), 226 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 3.1), spleen (RPKM 2.7) and 25 other tissues.

Summary

This gene encodes a protein that binds to one of the small heat shock proteins, specifically hsp27. Hsp27 is involved with cell growth and differentiation. This encoded protein was found to be abnormally expressed in patients with intractable epilepsy, although how brain function is affected remains unknown. [provided by RefSeq, Sep 2011]

HSPBAP1 Products (2)

mRNA	Protein	Name
NM_001320728.2	NP_001307657.1	HSPB1-associated protein 1 isoform 2
NM_024610.6	NP_078886.2	HSPB1-associated protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24981860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPBAP1 Protein Structure

Cupin_8

0
100
200
300
400
488 a.a.

Protein Preferred Names	Protein Names
HSPB1-associated protein 1	27 kDa heat shock protein-associated protein 1

HSPBAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	HSPBAP1	Q96EW2	NUTM1	Homo sapiens	Q86Y26	Y2H Array	25416956
Intra	HSPBAP1	Q96EW2	ABHD10	Homo sapiens	Q9NUJ1	Anti Tag CoIP	33961781
Intra	HSPBAP1	Q96EW2	ARHGEF5	Homo sapiens	Q12774	Validated Y2H	25416956
Intra	HSPBAP1	Q96EW2	ARHGEF5	Homo sapiens	Q12774	Y2H Prey Pooling	25416956
Intra	HSPBAP1	Q96EW2	NCALD	Homo sapiens	P61601	Anti Tag CoIP	33961781
Intra	HSPBAP1	Q96EW2	NCALD	Homo sapiens	P61601	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS06445	HSPBAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HSPBAP1	MGD	MGI:1913917
Rattus norvegicus	HSPBAP1	RGD	RGD:620870
Felis catus	HSPBAP1	VGNC	VGNC:97459
Bos taurus	HSPBAP1	VGNC	VGNC:29987
Macaca mulatta	HSPBAP1	VGNC	VGNC:81420
Canis familiaris	HSPBAP1	VGNC	VGNC:41819
Others	HSPBAP1	NCBI