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RNF7 - ring finger protein 7 Gene

Also Known as SAG; ROC2; rbx2; CKBBP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9616

About RNF7

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:141,738,298-141,747,560 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.8), adrenal (RPKM 15.8) and 25 other tissues.

Summary

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, Casein Kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

RNF7 Products (3)

mRNA	Protein	Name
NM_001201370.2	NP_001188299.1	RING-box protein 2 isoform 4
NM_014245.5	NP_055060.1	RING-box protein 2 isoform 1
NM_183237.3	NP_899060.1	RING-box protein 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables NEDD8 ligase activity	IDA IDA: Inferred from direct assay	19250909	GOA
enables cullin family protein binding	IDA IDA: Inferred from direct assay	10230407	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16325183	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	16874460	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	31387940	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	21980433	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	27910872	GOA
involved in protein neddylation	IDA IDA: Inferred from direct assay	19250909	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	21980433	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	16874460	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	16874460	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF7 Protein Structure

zf-rbx1

0
100
113 a.a.

Protein Preferred Names	Protein Names
RING-box protein 2	CKII beta-binding protein 1

RNF7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	RNF7	Q9UBF6	CUL5	Homo sapiens	Q93034	Y2H Array	25416956
Intra	RNF7	Q9UBF6	CUL5	Homo sapiens	Q93034	Anti Tag CoIP	33961781
Intra	RNF7	Q9UBF6	CUL5	Homo sapiens	Q93034	Validated Y2H	25416956
Intra	RNF7	Q9UBF6	ASB1	Homo sapiens	Q9Y576	Anti Tag CoIP	33961781
Intra	RNF7	Q9UBF6	ASB7	Homo sapiens	Q9H672	Anti Tag CoIP	33961781
Intra	RNF7	Q9UBF6	ASB6	Homo sapiens	Q9NWX5	Anti Tag CoIP	33961781
Intra	RNF7	Q9UBF6	IKBKG	Homo sapiens	Q9Y6K9	Pull Down	20098747
Intra	RNF7	Q9UBF6	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	20098747
Intra	RNF7	Q9UBF6	IKBKG	Homo sapiens	Q9Y6K9	Y2H	20098747

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Brachydactyly, Type E2	Brachydactyly Type E2 BDE2 Brachydactyly E2
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Cockayne Syndrome A	Cockayne Syndrome Type 1 Cockayne Syndrome, Type A Cockayne Syndrome Type I CSA Cockayne Syndrome Classic Form Cockayne Syndrome Classical Cockayne Syndrome Type A Ckn1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS12096	RNF7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RNF7	MGD	MGI:1337096
Canis familiaris	RNF7	VGNC	VGNC:45675
Macaca mulatta	RNF7	VGNC	VGNC:76707
Bos taurus	RNF7	VGNC	VGNC:34072
Felis catus	RNF7	VGNC	VGNC:102814
Rattus norvegicus	RNF7	RGD	RGD:1311048
Others	RNF7	NCBI