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Art. -Nr.: HY-N19290

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Glenthmycin E

Glenthmycin E is an antibacterial agent found in Australian sheep pasture-derived Streptomyces sp. CMB-PB041. Glenthmycin E inhibits growth of multiple bacterial and exhibits no detectable cytotoxicity to eukaryotic cells including fungal and human carcinoma cells. Glenthmycin E can be used for the research of bacterial infections.

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CAS. Nr.: 3040055-84-0
Formel: C₅₀H₆₄O₁₄
Molecular Weight:889.03

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Glenthmycin E Chemical Structure

CAS. Nr.: 3040055-84-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H460	IC₅₀	30 μM Compound: 5	Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay	[PMID: 35640100]

In Vitro

Glenthmycin E (0.01-30 μM; 16-24 h) inhibits the growth of Staphylococcus aureus ATCC 25923 (IC₅₀ = 4.9 μM), Enterococcus faecalis (IC₅₀ = 6.2 μM), methicillin-resistant S. aureus ATCC 43300 (IC₅₀ = 3.9 μM), methicillin-resistant S. aureus ATCC 33591 (IC₅₀ = 2.3 μM), and vancomycin-resistant Enterococci (IC₅₀ = 3.2 μM)^[1].
Glenthmycin E (48 h) does not exhibit significant cytotoxicity against SW620 or NCI-H460 human carcinoma cells (IC₅₀ >30 μM), nor does it inhibit growth of Candida albicans, Escherichia coli, Mycobacterium bovis BCG, or Mycobacterium tuberculosis H37Ra at concentrations up to 30 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human colorectal carcinoma (SW620), human lung carcinoma (NCI-H460) cells
Concentration:

10 nM-30 μM
Incubation Time:

48 h
Result:

Exhibited no significant cytotoxicity against SW620 or NCI-H460 cells (IC₅₀ >30 μM).

Chemical Information

CAS. Nr. 3040055-84-0
Molecular Weight 889.03
Formel C₅₀H₆₄O₁₄
SMILES

C[C@@]12[C@@]3(C[C@H](C(C(O)=O)=C2)C)C(O)=C(C([C@]4([C@@]5([H])[C@@](C=C([C@@]4([H])/C(C)=C/CC/C(C)=C/1)C)([H])[C@H](CC[C@@H]5C)O[C@H]6[C@@H]([C@@H]([C@@H]([C@H](O6)C)OC(C7=C(C=C(C=C7C)OC)OC)=O)O)O)C)=O)C(O3)=O
Structure Classification
- Phenols
- Monophenols
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Streptomyces sp.
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Wu T, et al. Glenthmycins A-M: Macrocyclic Spirotetronate Polyketide Antibacterials from the Australian Pasture Plant-Derived Streptomyces sp. CMB-PB041. J Nat Prod. 2022 Jun 24;85(6):1641-1657. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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