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Art. -Nr.: HY-186061A

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HCN2 modulator-8

HCN2 modulator-8 is a pyrazolopyridine derivative and selective HCN2 inhibitor. HCN2 modulator-8 can be used for the research of pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3080809-12-4
Formel: C₂₁H₁₈FN₅O₄S
Molecular Weight:455.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

HCN2 modulator-8 Chemical Structure

CAS. Nr.: 3080809-12-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

KCNQ2

In Vitro

HCN2 modulator-8 (S-configuration 49) potently and selectively inhibited human HCN2 channels, with an HCN2 IC₅₀ of 3 nM, HCN1 IC₅₀ of 186 nM, and HCN4 IC₅₀ of 87 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3080809-12-4
Molecular Weight 455.46
Formel C₂₁H₁₈FN₅O₄S
SMILES

O=C(C1=CC=NS1)NC2=NN(C[C@H](C)OC)C3=NC=C(C4=CC=C(OCO5)C5=C4F)C=C23
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ashok Arasappan, et al. Azaindazole derivatives useful as hcn2 modulators. WO2025072040A1.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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