HK2-IN-3

HK2-IN-3 (compound 12) potently inhibits purified HK2 enzyme with an IC₅₀ of 0.0564 μM^[1].
HK2-IN-3 (100 ns) binds selectively and stably to HK2 over HK1, with binding energies ranging between -190 and -270 kcal/mol and persistent interactions with critical HK2 active site residues^[1].
HK2-IN-3 (1-5 μM; 72 h) reduces glucose uptake in Cal27 and FaDu OSCC cells when treated at 1, 3, or 5 μM for 72 h^[1].
HK2-IN-3 inhibits proliferation of FaDu and Cal27 OSCC cells with GI₅₀ values of 8.32 μM and 7.18 μM, respectively, and shows high selectivity for OSCC cells over HFF-1 normal fibroblasts^[1].
HK2-IN-3 (5 μM) disrupts the 3D structure of Cal27 OSCC spheroids and increases cell death when treated at 5 μM^[1].
HK2-IN-3 (10-30 μM; 4 h) induces mitophagy in Cal27 OSCC cells when treated at 30 μM for 4 h, via dissociation of mitoHK2, increased LC3B levels, and decreased p62 levels in mitochondrial fractions^[1].
HK2-IN-3 (3-30 μM; 72 h) downregulates expression of GLUT1, GLUT4, EGFR, and VEGF in Cal27 OSCC cells when treated at 30 μM for 72 h, with partial inhibition of GLUT1 observed at 10 μM^[1].
HK2-IN-3 (5 μM; 72 h) induces early to late apoptosis in Cal27 OSCC cells when treated at 5 μM for 72 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.