HOI-07
HOI-07 is a selective Aurora B kinase inhibitor. HOI-07 blocks phosphorylation of histone H3 on Ser10 in lung cancer cells. HOI-07 induces cell-cycle arrest, and apoptosis. HOI-07 has antitumor activity, and suppresses the tumor growth of A549, 143B and KHOS xenografts.
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- CAS. Nr.: 1451013-67-4
- Formel: C19H13NO4
- Molecular Weight:319.31
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
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Biologische Aktivität
Chemical Information
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CAS. Nr. 1451013-67-4
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Molecular Weight 319.31
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Formel C19H13NO4
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SMILES
O=C1NC2=C(/C1=C\C(/C=C/C3=CC=C4OCOC4=C3)=O)C=CC=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Xie H, et al. Identification of an Aurora kinase inhibitor specific for the Aurora B isoform. Cancer Res. 2013 Jan 15;73(2):716-24. [Content Brief]
[2]. Zhao Z, et al. Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma. Mol Carcinog. 2019 Jun;58(6):1056-1067. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HOI-07 Related Classifications
HY-125158 Related Classifications
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