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Art. -Nr.: HY-167655

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KF-19418

KF-19418 is a hair follicle stimulator with hair growth promoting activity. KF-19418 stimulates proliferation of cultured hair bulb cells from newborn mice. KF-19418 accelerates hair regrowth in hair-clipped mouse alopecia model following topical application. KF-19418 can be used for the research of alopecia.

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CAS. Nr.: 147508-06-3
Formel: C₂₁H₁₄N₄O
Molecular Weight:338.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

KF-19418 Chemical Structure

CAS. Nr.: 147508-06-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

KF-19418 (0.001-10 μM; 4 days) concentration-dependently stimulates proliferation of hair bulb cells isolated from 4-day-old C3H/HeN mice, reaching ~240% of control growth at 10 μM over 4 days, while maintaining immature cell morphology and melanocyte populations^[1].
KF-19418 (3-10 μM; 3 days) promotes hair follicle elongation in cultured whole skin pieces from 4-week-old C3H mice in anagen phase, with 10 μM increasing tissue area by ~13% over 3 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KF-19418 (1% suspension; topical; daily; 2 weeks) promotes hair regrowth in a mouse alopecia model, with a hair-regrown area ratio of 38.4%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C3H mice (8-week-old, telogen phase)^[1]
Dosage:

1% suspension
Administration:

topical; daily; 2 weeks
Result:

Reached a hair-regrown area to shaved area ratio of 38.4%.
Showed visible hair regrowth after 1 week of application.
Caused no visible skin abnormalities (e.g., inflammation).

Chemical Information

CAS. Nr. 147508-06-3
Molecular Weight 338.36
Formel C₂₁H₁₄N₄O
SMILES

O=C1C2=C(C3=C(N1C4=CC=CC=C4)N=CC=C3)NN=C2C5=CC=CC=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shirai A, et al. KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models. J Dermatol Sci. 2001;25(3):213-218. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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