L 743310
L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis.
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- CAS. Nr.: 187724-86-3
- Formel: C30H33BrF6N4O2
- Molecular Weight:675.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
hNK1 receptor[1]
Chemical Information
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CAS. Nr. 187724-86-3
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Molecular Weight 675.50
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Formel C30H33BrF6N4O2
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SMILES
C[N+]1(CC2)CCC2(NC(NC(CC3=CNC4=C3C=CC=C4)C(CCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)=O)CC1.[Br-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
L 743310 Related Classifications
HY-117952 Related Classifications
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