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Art. -Nr.: HY-174412

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LC-PDin06

LC-PDin06 is a selective PRDX1 inhibitor with an IC₅₀ of 0.042 μM. LC-PDin06, a Celastrol (HY-13067) derivative, shows potent antiproliferative activity against colorectal cancer cells by significantly increasing ROS levels.

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CAS. Nr.: 2027514-32-3
Formel: C₃₅H₄₇N₃O₃
Molecular Weight:557.77

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (244 KB)

LC-PDin06 Chemical Structure

CAS. Nr.: 2027514-32-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

0.042 μM

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.37 μM Compound: CEL21	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 27647369]
MCF7	IC₅₀	1.84 μM Compound: CEL21	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 27647369]
PANC-1	IC₅₀	1.53 μM Compound: CEL21	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 27647369]

Chemical Information

CAS. Nr. 2027514-32-3
Molecular Weight 557.77
Formel C₃₅H₄₇N₃O₃
SMILES

OC1=C(C)C2=CC=C3[C@@]4(C)CC[C@@]5(C)CC[C@@](C)(C(NCCCN6C=CN=C6)=O)C[C@]([H])5[C@@](C)4CC[C@](C)3C2=CC1=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.