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Art. -Nr.: HY-184154

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LC1236

LC1236 is a thymidylate synthase (hTS) dimer dissociator with a target K_d of 7 μM and poor transmembrane permeability. LC1236 inhibits enzymatic activity by shifting the monomer-dimer equilibrium toward inactive monomers. LC1236 acts as a cytotoxic agent to inhibit cancer cell growth, and exerts synergistic cytotoxicity with electroporation via enhancing intracellular accumulation. LC1236 can be used in the research of cancers such as ovarian cancer and colorectal cancer.

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CAS. Nr.: 2756347-47-2
Formel: C₂₁H₁₆N₂O₅S
Molecular Weight:408.43

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

LC1236 Chemical Structure

CAS. Nr.: 2756347-47-2

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

LC1236 (50–100 μM; 72 h), when combined with electroporation, exhibited synergistically enhanced cytotoxicity in A2780 ovarian cancer cells, A2780/CP Cisplatin (HY-17394)-resistant ovarian cancer cells, and HCT116 colorectal adenocarcinoma cells, overcoming its intrinsic poor cell membrane permeability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2756347-47-2
Molecular Weight 408.43
Formel C₂₁H₁₆N₂O₅S
SMILES

O=C(NC1=CC=C(C(O)=O)C=C1)C(C2=CC=CC=C2)SC3=CC=C([N+]([O-])=O)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Marverti G, et al. Increased Ovarian and Colorectal Cancer Cell Sensitivity to Platinum Drugs and innovative TS Inhibitors by Electroporation. bioRxiv. 2026:2026-05.

[2]. Costantino L, et al. Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth. Elife. 2022;11:e73862. Published 2022 Dec 7. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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