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Art. -Nr.: HY-155851

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Lepadin E

Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect.

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CAS. Nr.: 444914-19-6
Formel: C₂₆H₄₇NO₃
Molecular Weight:421.66

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Lepadin E Chemical Structure

CAS. Nr.: 444914-19-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
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Calculators
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

ACSL4

Alle ACSL Family Isoform-spezifische Produkte anzeigen :

ACSL4
ACSL5

Alle Glutathione Peroxidase Isoform-spezifische Produkte anzeigen :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	5.93 μM Compound: Lepadin E	Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
HeLa	IC₅₀	2.67 μM Compound: Lepadin E	Cytotoxicity against human HeLa cells incubated for 72 hrs by MTT assay Cytotoxicity against human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
HepG2	IC₅₀	6.2 μM Compound: Lepadin E	Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
L02	IC₅₀	18.72 μM Compound: Lepadin E	Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
MCF7	IC₅₀	5.95 μM Compound: Lepadin E	Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
MDA-MB-231	IC₅₀	8.04 μM Compound: Lepadin E	Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
NCI-H1155	IC₅₀	7.88 μM Compound: Lepadin E	Cytotoxicity against human NCI-H1155 cells incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1155 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
NCI-H1355	IC₅₀	8.8 μM Compound: Lepadin E	Cytotoxicity against human NCI-H1355 cells incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1355 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
SH-SY5Y	IC₅₀	6.19 μM Compound: Lepadin E	Cytotoxicity against human SH-SY5Y cells incubated for 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
SK-OV-3	IC₅₀	7.94 μM Compound: Lepadin E	Cytotoxicity against human SK-OV-3 cells incubated for 72 hrs by MTT assay Cytotoxicity against human SK-OV-3 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
SMMC-7721	IC₅₀	3.93 μM Compound: Lepadin E	Cytotoxicity against human SMMC-7721 cells incubated for 72 hrs by MTT assay Cytotoxicity against human SMMC-7721 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]

Chemical Information

CAS. Nr. 444914-19-6
Molecular Weight 421.66
Formel C₂₆H₄₇NO₃
SMILES

CCC[C@H](CCCC[C@@H](CCC[C@@]12[H])[C@]2([H])C[C@H]([C@@H](N1)C)OC(/C=C/CCCCC)=O)O
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
- Marine natural products
- Other marine organisms
- Animals
Tropical Marine Tunicate Didemnum sp.
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66(16):11201-11215. [Content Brief]

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Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Lepadin E

Alle ACSL Family Isoform-spezifische Produkte anzeigen

Alle Glutathione Peroxidase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Lepadin E Related Classifications

HY-155851 Related Classifications