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Art. -Nr.: HY-182547

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LY580276

LY580276 is an ATP-competitive ALK5 inhibitor with an IC₅₀ of 175 nM. LY580276 inhibits transforming growth factor-β-induced epithelial-mesenchymal transition. LY580276 can be used for cancer research.

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CAS. Nr.: 476475-07-7
Formel: C₁₈H₁₆FN₃
Molecular Weight:293.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

LY580276 Chemical Structure

CAS. Nr.: 476475-07-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
NIH3T3	IC₅₀	0.339 μM Compound: 15	Inhibitory activity tested in NIH 3T3 cells Inhibitory activity tested in NIH 3T3 cells	[PMID: 15177480]

In Vitro

LY580276 potently and selectively inhibits ALK5 kinase activity with an IC₅₀ of 175 nM, blocks TGF-β-mediated cellular signalling with an IC₅₀ of 96 nM, and shows minimal activity against p38 MAP kinase (IC₅₀ >10 μM)^[1].
LY580276 (2 μM) inhibits TGF-β-induced epithelial-to-mesenchymal transition in normal murine mammary epithelial (NMuMG) cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 476475-07-7
Molecular Weight 293.34
Formel C₁₈H₁₆FN₃
SMILES

FC1=CC=C(C2=C(CCC3)N3N=C2C4=CC=CC(C)=N4)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Yingling JM, Blanchard KL, Sawyer JS. Development of TGF-beta signalling inhibitors for cancer therapy. Nat Rev Drug Discov. 2004 Dec;3(12):1011-22.
[Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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