MAIT-203
MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C106H177N43O29
- Molecular Weight:2517.85
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
MAIT-203 (10 μM and 25 μM; for 24 h) reduces Asef-APC interaction in a dose-dependent manner in HEK293T cells[1].
MAIT-203 (10 μM) significantly attenuates SW480 and HCT116 cell migration[1].
Incubation of SW480 cells with MAIT-203 (25, 50 μM;for 24 h) results in a dose-dependent decrease in the amount of the active form of CDC42, but not Rac1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 2517.85
-
Formel C106H177N43O29
-
Sequence
Cbz-Ala-Gly-Glu-Ala-{S-3cyclopentylalamine}-Tyr-Glu-Gly-Gly-Gly-Gly-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
-
Sequence Shortening
Z-AGEA-{S-3cyclopentylalamine}-YEGGGGGRKKRRQRRR-NH2
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Powered by Bioz