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Art. -Nr.: HY-12689S

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Mitapivat-d₈

(Synonyms: AG-348-d₈)

Mitapivat-d₈ (AG-348-d₈) is the deuterium labeled Mitapivat (HY-12689). Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₄H₁₈D₈N₄O₃S
Molecular Weight:458.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mitapivat-d₈ Chemical Structure

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Biologische Aktivität
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Biologische Aktivität

Beschreibung

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 1260075-17-9
Molecular Weight 458.60
Formel C₂₄H₁₈D₈N₄O₃S
SMILES

O=S(C1=C2N=CC=CC2=CC=C1)(NC3=CC=C(C(N4C([2H])([2H])C([2H])([2H])N(CC5CC5)C([2H])([2H])C4([2H])[2H])=O)C=C3)=O
Synonyms

AG-348-d₈
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.