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Art. -Nr.: HY-106065

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Mitozolomide

Name: Mitozolomide
Brand: MedChemExpress
SKU: HY-106065
Price: 176.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: M & B 39565; CCRG 81010; NSC 353451)

Mitozolomide (M & B 39565) is a prodrug of alkyldiazonium reactive intermediates. Mitozolomide can be converted in vivo to triazenes.

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CAS. Nr.: 85622-95-3
Formel: C₇H₇ClN₆O₂
Molecular Weight:242.62

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (267 KB)

Mitozolomide Chemical Structure

CAS. Nr.: 85622-95-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Mitozolomide (M & B 39565) is a prodrug of alkyldiazonium reactive intermediates. Mitozolomide can be converted in vivo to triazenes^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast	IC₅₀	20 μM Compound: Mitozolomide	In vitro cytotoxicity against human xeroderma pigmentosum fibroblast cells HMGZip (mer-) In vitro cytotoxicity against human xeroderma pigmentosum fibroblast cells HMGZip (mer-)	[PMID: 12459014]
Fibroblast	IC₅₀	30 μM Compound: Mitozolomide	In vitro cytotoxicity against human xeroderma pigmentosum fibroblast cells HMGZAT (mer+) In vitro cytotoxicity against human xeroderma pigmentosum fibroblast cells HMGZAT (mer+)	[PMID: 12459014]
GM892A cell line	IC₅₀	4.8 μM Compound: 2	In vitro cytotoxicity against human lymphoblastoid cell line (GM892 A) In vitro cytotoxicity against human lymphoblastoid cell line (GM892 A)	[PMID: 7739008]
HCT-116	IC₅₀	17.9 μM Compound: MTZ	Chemosensitization of p53-deficient human HCT116 cells after 5 days by MTT assay Chemosensitization of p53-deficient human HCT116 cells after 5 days by MTT assay	[PMID: 23895620]
HCT-116	IC₅₀	60 μM Compound: MTZ	Chemosensitization of human HCT116 cells expressing p53 after 5 days by MTT assay Chemosensitization of human HCT116 cells expressing p53 after 5 days by MTT assay	[PMID: 23895620]
Raji	IC₅₀	39 μM Compound: 2	In vitro cytotoxicity against Raji cell line In vitro cytotoxicity against Raji cell line	[PMID: 7739008]
SNB-19	GI₅₀	10 μM Compound: 2; MTZ	Growth inhibition of empty vector transfected human SNB19 cells after 7 days by MTT assay Growth inhibition of empty vector transfected human SNB19 cells after 7 days by MTT assay	10.1039/C6MD00384B
SNB-19	GI₅₀	68.4 μM Compound: 2; MTZ	Growth inhibition of MGMT-transfected human SNB19 cells after 7 days by MTT assay Growth inhibition of MGMT-transfected human SNB19 cells after 7 days by MTT assay	10.1039/C6MD00384B
TLX-5	IC₅₀	2.5 μM Compound: 2	In vitro cytotoxicity against mouse TLX5 lymphoma cells In vitro cytotoxicity against mouse TLX5 lymphoma cells	[PMID: 7739008]
U-373MG ATCC	GI₅₀	22 μM Compound: 2; MTZ	Growth inhibition of empty vector transfected human U373 cells after 7 days by MTT assay Growth inhibition of empty vector transfected human U373 cells after 7 days by MTT assay	10.1039/C6MD00384B
U-373MG ATCC	GI₅₀	40.3 μM Compound: 2; MTZ	Growth inhibition of MGMT-transfected human U373 cells after 7 days by MTT assay Growth inhibition of MGMT-transfected human U373 cells after 7 days by MTT assay	10.1039/C6MD00384B

Chemical Information

CAS. Nr. 85622-95-3
Appearance Solid
Molecular Weight 242.62
Formel C₇H₇ClN₆O₂
Color Light brown to brown
SMILES

O=C(C(N=CN12)=C2N=NN(CCCl)C1=O)N
Synonyms

M & B 39565; CCRG 81010; NSC 353451
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Stevens MFG, et, al. Antitumour imidazotetrazines: past, present… and future? RSC Chem Biol. 2023 Aug 29;4(10):736-741. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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