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Art. -Nr.: HY-111282

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MK-789

MK-789 is a competitive reversible inhibitor of dehydropeptidase I (DHP-I). MK-789 competitively blocks the entry of N-formimidoylthienamycin into proximal tubular cells, thereby inhibiting its renal metabolism. MK-789 shifts the renal excretion pathway of N-formimidoylthienamycin to glomerular filtration only, increasing its urinary recovery rate and renal clearance. MK-789 is applicable to studies on renal metabolism and pharmacokinetics.

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CAS. Nr.: 85394-14-5
Formel: C₁₄H₂₃NO₃
Molecular Weight:253.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

MK-789 Chemical Structure

CAS. Nr.: 85394-14-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Dipeptidyl Peptidase Isoform-spezifische Produkte anzeigen :

In Vitro

MK-789 and its oxidative metabolites inhibit purified dehydropeptidase I in spectrophotometric assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MK-789 (25, 75, 150 mg; intravenous injection; single administration; 7-day washout period between each dose) increases the urinary recovery rate of co-administered 150 mg N-formimidoylthienamycin to a plateau value of approximately 61% in healthy Caucasian male subjects; it elevates the plasma AUC of co-administered N-formimidoylthienamycin by approximately 20% without altering its plasma half-life^[1].\n

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 85394-14-5
Molecular Weight 253.34
Formel C₁₄H₂₃NO₃
SMILES

O=C(/C(NC(C1CC1(C)C)=O)=C\CCCCC)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Norrby SR, et al. Urinary recovery of N-formimidoyl thienamycin (MK0787) as affected by coadministration of N-formimidoyl thienamycin dehydropeptidase inhibitors. Antimicrobial agents and chemotherapy. 1983 Feb;23(2):300-7. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vivo
Chemical Information
Reinheit & Dokumentation
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MK-789

Alle Dipeptidyl Peptidase Isoform-spezifische Produkte anzeigen