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Art. -Nr.: HY-162313

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NIP-22c

NIP-22c is a novel coronavirus 3CL_pro inhibitor. The EC₅₀ for Verona, Calu3, Caco2 and HBTEC-ALI were 4.6, 1.1, 0.1 and 0.6 μM, respectively. NIP-22c has antiviral activity.

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CAS. Nr.: 2309384-85-6
Formel: C₃₂H₃₉N₅O₆
Molecular Weight:589.68

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

NIP-22c Chemical Structure

CAS. Nr.: 2309384-85-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

NIP-22c is a novel coronavirus 3CL_pro inhibitor. The EC₅₀ for Verona, Calu3, Caco2 and HBTEC-ALI were 4.6, 1.1, 0.1 and 0.6 μM, respectively. NIP-22c has antiviral activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	CC₅₀	>100 μM Compound: 22c	Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability	[PMID: 38432056]
Calu-3	CC₅₀	>100 μM Compound: 22c	Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability	[PMID: 38432056]
CCRF-CEM	CC₅₀	13.9 μM Compound: 22c	Cytotoxicity against human CEM cells assessed as reduction in cell viability Cytotoxicity against human CEM cells assessed as reduction in cell viability	[PMID: 38432056]
Huh-7	CC₅₀	32.7 μM Compound: 22c	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability	[PMID: 38432056]
PBMC	CC₅₀	30.9 μM Compound: 22c	Cytotoxicity against human PBMC cells assessed as reduction in cell viability Cytotoxicity against human PBMC cells assessed as reduction in cell viability	[PMID: 38432056]
Vero	CC₅₀	84.3 μM Compound: 22c	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability	[PMID: 38432056]

Chemical Information

CAS. Nr. 2309384-85-6
Molecular Weight 589.68
Formel C₃₂H₃₉N₅O₆
SMILES

O=C(N[C@@H](CC(C)C)C(N[C@@H](C[C@@H]1CCCNC1=O)C=O)=O)[C@@H](NC(C2=NOC(C)=C2)=O)CC3=CC=CC4=C3C=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Amblard F, et al. Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease. Eur J Med Chem. 2024 Feb 24;268:116263. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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