NW 1028
NW 1028 is a potent VCP/p97 inhibitor. NW 1028 targets the ND1L domain of p97 and inhibits the degradation of a p97-dependent reporter. NW 1028 has good binding affinity with Kd values of 100 and 285 nM for ND1L and full length p97, respectively. NW 1028 has the function of regulating the mitotic spindle of cells.
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- CAS. Nr.: 2749599-78-6
- Formel: C19H21N5O4S
- Molecular Weight:415.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
NW1028 (0.1-10 µM) inhibits the ATPase activity of the D1 domain and do not impact the ATPase activity of the D2 domain[1].
NW1028 (0.0001-100 µM; 72 h; HeLa K cells) does not cause cell death and does not activate the UPR response[1].
NW1028 (10 μM; HeLa cells) affects the orientation of the mitotic spindle. NW1028 has a spindle orientation defect in the z axis with 53.9%, compared to 14.9% cells in control conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS. Nr. 2749599-78-6
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Molecular Weight 415.47
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Formel C19H21N5O4S
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SMILES
O=C(C1=CC(NC(N2)=S)=C(C=C1)C2=O)N3[C@H](C(N4[C@H](C(N)=O)CCC4)=O)CCC3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NW 1028 Related Classifications
HY-148122 Related Classifications
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