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Art. -Nr.: HY-180321

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OAT-1441

OAT-1441 is a selective hAMCase inhibitor with oral activity (IC₅₀ = 7 nM). OAT-1441 can be used to study the physiological functions of hAMC enzymes.

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CAS. Nr.: 2088453-79-4
Formel: C₂₃H₂₇ClN₆O
Molecular Weight:438.96

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

OAT-1441 Chemical Structure

CAS. Nr.: 2088453-79-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

OAT-1441 is a selective hAMCase inhibitor with oral activity (IC₅₀ = 7 nM). OAT-1441 can be used to study the physiological functions of hAMC enzymes^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	23000 nM Compound: 11; OAT-1441	Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch-clamp assay Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch-clamp assay	[PMID: 32551005]

Chemical Information

CAS. Nr. 2088453-79-4
Molecular Weight 438.96
Formel C₂₃H₂₇ClN₆O
SMILES

C([C@@H]1N(CC=2C(OC1)=CC=CC2)C3CCN(CC3)C=4NC(N)=NN4)C5=CC=C(Cl)C=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Andryianau G,et al. Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett. 2020 Apr 24;11(6):1228-1235. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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