PD-134672
PD-134672 (CI-992) is a renin inhibitor containing a 2-amino-4-thiazolyl substituent. PD-134672 potently inhibits monkey renin in vitro and only weakly inhibits the related aspartic protease bovine feline hepsin D. The compound exhibits oral hypotensive activity in hyperreninemic normotensive monkeys. Based on its superior efficacy and long-lasting effects in vitro and in the normotensive macaque model, PD-134672 was selected for further evaluation in renal hypertensive monkeys.
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- CAS. Nr.: 135704-06-2
- Formel: C33H52N6O7S2
- Molecular Weight:708.93
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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CAS. Nr. 135704-06-2
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Molecular Weight 708.93
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Formel C33H52N6O7S2
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SMILES
O=S(N[C@H](C(N[C@H](C(N[C@@]([C@@H](O)[C@@H](O)CC(C)C)([H])CC1CCCCC1)=O)CC2=CSC(N)=N2)=O)CC3=CC=CC=C3)(N4CCOCC4)=O
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Synonyms
CI-992
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PD-134672 Related Classifications
HY-19145 Related Classifications
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