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Art. -Nr.: HY-158208

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PMMB276

PMMB276 is a potent inhibitor of β-tubulin isotype III (Tubb3) polymerization and induced apoptosis. PMMB276 plays an important role in cancer research.

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CAS. Nr.: 2209036-28-0
Formel: C₃₁H₃₄O₆S₂
Molecular Weight:566.73

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

PMMB276 Chemical Structure

CAS. Nr.: 2209036-28-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PMMB276 is a potent inhibitor of β-tubulin isotype III (Tubb3) polymerization and induced apoptosis. PMMB276 plays an important role in cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	16.37 μM Compound: 1c	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 29268130]
HEK-293T	IC₅₀	88.83 μM Compound: 1c	Antiproliferative activity against human 293T cells after 24 hrs by MTT assay Antiproliferative activity against human 293T cells after 24 hrs by MTT assay	[PMID: 29268130]
HeLa	IC₅₀	3.14 μM Compound: 1c	Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay	[PMID: 29268130]
HepG2	IC₅₀	5.37 μM Compound: 1c	Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 29268130]
L02	IC₅₀	116.2 μM Compound: 1c	Antiproliferative activity against human LO2 cells after 24 hrs by MTT assay Antiproliferative activity against human LO2 cells after 24 hrs by MTT assay	[PMID: 29268130]
MDA-MB-231	IC₅₀	17.67 μM Compound: 1c	Antiproliferative activity against human MDA231 cells after 24 hrs by MTT assay Antiproliferative activity against human MDA231 cells after 24 hrs by MTT assay	[PMID: 29268130]

Chemical Information

CAS. Nr. 2209036-28-0
Appearance Solid
Molecular Weight 566.73
Formel C₃₁H₃₄O₆S₂
Color Brown to reddish brown
SMILES

O=C(C1=C(C=CC(O)=C12)O)C=C([C@@H](C/C=C(C)/C)OC(CCCC[C@H]3SC(SCC3)C4=CC=CC=C4)=O)C2=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hongwei Han, et al. A modified natural small molecule inhibits triple-negative breast cancer growth by interacting with Tubb3. Phytomedicine. 2024 Apr:126:154894. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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PMMB276

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

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Help & FAQs

PMMB276 Related Classifications

HY-158208 Related Classifications