DAPK2
DAPK2, death-associated protein kinase 2, is a calcium/calmodulin-regulated serine/threonine kinase sharing the catalytic and calmodulin-binding architecture of DAPK1 but lacking its long carboxy-terminal extensions and death domain. DAPK2 forms autoinhibited homodimers that are relieved upon calmodulin binding. It phosphorylates myosin regulatory light chain, modulating cytoskeletal dynamics during cell death, and its overexpression induces apoptosis in multiple cell lines, including hematopoietic contexts where DAPK2 expression is prominent. Reduced expression through promoter methylation has been described in several malignancies, consistent with tumor suppressor behavior, and the enzyme has additionally been implicated in granulocytic differentiation, linking death signaling to myeloid lineage decisions.
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DAPK2 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
