ULK3
ULK3 diverges from ULK1 and ULK2 by functioning chiefly outside canonical autophagy initiation. It is a positive regulator of Sonic hedgehog signaling: ULK3 binds Suppressor of Fused and the Gli proteins and is required for activation of Gli target genes, and its overexpression drives Hedgehog-dependent proliferation in medulloblastoma models. ULK3 also participates in ciliogenesis, DNA-damage responses and, in some contexts, autophagy induction under stress. Expression is prominent during neural development and in adult brain. Because ULK3 links a kinase module to developmental signaling rather than to the core autophagy machinery, recombinant ULK3 is valuable for dissecting pathway-specific ULK-family functions.
-
ULK3 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
