PT150
Based on 1 Customer Validation
PT150 (ORG-34517) is a competitive and orally active glucocorticoid receptor antagonist. PT150 shows neuroprotective effects. PT150 has the potential for the research of Parkinson’s disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 96.70%
- CAS. Nr.: 189035-07-2
- Formel: C28H30O4
- Molecular Weight:430.54
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Clinical Compound Library
HY-L026
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Drug Repurposing Compound Library
HY-L035
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Orally Active Compound Library
HY-L061
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Neuroprotective Compound Library
HY-L070
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Antidepressant Compound Library
HY-L108
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Nuclear Receptor Compound Library
HY-L126
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Pain-Related Compound Library
HY-L139
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
HY-L001V
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Drug Repurposing Compound Library Plus
HY-L035P
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Clinical Compound Library Plus
HY-L026P
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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HY-L258
Biologische Aktivität
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl/6 mice (2.5 mg/kg/day rotenone by intraperitoneal injection for 14 days)[2]
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Dosage:30, 100 mg/kg
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Administration:P.o.; daily for 14 days
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Result:Reduced the loss of dopaminergic neuron (DAn) cell bodies in the substantia nigra (SN), but not the striatum, and prohibited intra-neuronal accumulation of α-synuclein (α-syn).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 189035-07-2
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Appearance Solid
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Molecular Weight 430.54
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Formel C28H30O4
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Color White to light yellow
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SMILES
O[C@]1(C#CC)[C@]2(C)[C@H]([C@H](CC3)C([C@@H](C4=CC5=C(C=C4)OCO5)C2)=C6C3=CC(CC6)=O)CC1
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Synonyms
ORG-34517
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Morice C, et al. A randomized trial of safety and pharmacodynamic interactions between a selective glucocorticoid receptor antagonist, PT150, and ethanol in healthy volunteers. Sci Rep. 2021 May 10;11(1):9876. [Content Brief]
[2]. Latham AS, et al. Neuroprotective Efficacy of the Glucocorticoid Receptor Modulator PT150 in the Rotenone Mouse Model of Parkinson's Disease. bioRxiv [Preprint]. 2024 Apr 15:2024.04.12.589261. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PT150 Related Classifications
HY-125558 Related Classifications
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