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Art. -Nr.: HY-182453

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RM1490

RM1490 (Compound 251) acts as an inhibitor of μ-opioid receptor (MOR) (IC₅₀ ≤ 300 nM), an activator of δ-opioid receptor (DOR) (EC₅₀ > 3000 nM), and an inhibitor of κ-opioid receptor (KOR) (IC₅₀ ≤ 300 nM). RM1490 is applicable to the research of neuropsychiatric disorders.

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CAS. Nr.: 2849392-47-6
Formel: C₂₅H₃₄N₂O₂
Molecular Weight:394.55

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

RM1490 Chemical Structure

CAS. Nr.: 2849392-47-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

μ Opioid Receptor/MOR

≤ 300 nM (IC₅₀)

δ Opioid Receptor/DOR

> 3000 nM (EC₅₀)

κ Opioid Receptor/KOR

≤ 300 nM (IC₅₀)

Alle Opioid Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

RM1490 (Compound 251) (Serially diluted concentrations; 15 minutes at 37°C, 5% CO₂ plus 15 minutes at room temperature) potently antagonizes the mu opioid receptor in CHO Tag-lite human mOR stable cells with an IC₅₀ ≤ 300 nM^[1].
RM1490 (Compound 251) acts as a weak agonist of the delta opioid receptor with an EC₅₀ > 3000 nM^[1].
RM1490 (Compound 251) potently antagonizes kappa opioid receptor β-arrestin signaling with an IC₅₀ ≤ 300 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2849392-47-6
Molecular Weight 394.55
Formel C₂₅H₃₄N₂O₂
SMILES

CC(C=C(C=C1C)O)=C1C[C@H](N(C)C)CNC(C[C@H](C2=CC=CC=C2)C3CC3)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Julio Cesar Medina, et al. Opioid receptor modulators. WO2022216750A1. WIPO (PCT). 2022-04-05.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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RM1490

Alle Opioid Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

RM1490 Related Classifications

HY-182453 Related Classifications