Terbucarb
Terbucarb is a phenylcarbamate herbicide. Terbucarb disrupts the mitotic microtubule organizing centers in plant cells, leading to the formation of multipolar spindles and branched phragmoplasts, thereby inhibiting plant growth. An "anaphase star" pattern induced by Terbucarb is observed in onion root tips. Terbucarb is cytotoxic to isolated rat hepatocytes, inducing cell death accompanied by depletion of intracellular ATP, protein thiols and glutathione.
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- CAS. Nr.: 1918-11-2
- Formel: C17H27NO2
- Molecular Weight:277.41
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Terbucarb (27.7-277 μg/mL; 48 h) significantly induces the formation of micronuclei and multinucleated cells in hamster lung cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 (male, 8 weeks old, 30 g)[1]
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Dosage:1000 mg/kg
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Administration:p.o.; single dose
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Result:Showed a mean frequency of micronucleated reticulocytes of 1.3 per 1000 reticulocytes at 24 hours post-treatment.
Showed a mean frequency of micronucleated reticulocytes of 3.0 per 1000 reticulocytes at 48 hours post-treatment.
Showed a mean frequency of micronucleated reticulocytes of 1.3 per 1000 reticulocytes at 72 hours post-treatment.
Demonstrated no statistically significant increase in micronucleated reticulocyte frequencies relative to the concurrent corn oil control group at all time points.
Chemical Information
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CAS. Nr. 1918-11-2
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Molecular Weight 277.41
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Formel C17H27NO2
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SMILES
O=C(OC=1C(=CC(=CC1C(C)(C)C)C)C(C)(C)C)NC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Terbucarb Related Classifications
HY-W721611 Related Classifications
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