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Art. -Nr.: HY-125357

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Ternatin

Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC₅₀ of 0.027 μM in 3T3-L1 adipocytes.

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CAS. Nr.: 148619-41-4
Formel: C₃₇H₆₇N₇O₈
Molecular Weight:737.97

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ternatin Chemical Structure

CAS. Nr.: 148619-41-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Protokoll (2)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
3T3-L1	IC₅₀	0.027 μM Compound: 1	Inhibition of fat accumulation in mouse 3T3L1 cells assessed as liberated triglyceride after 7 days Inhibition of fat accumulation in mouse 3T3L1 cells assessed as liberated triglyceride after 7 days	[PMID: 18798610]
3T3-L1	IC₅₀	0.027 μM Compound: 1	Inhibition of fat accumulation in mouse 3T3L1 cells after 7 days Inhibition of fat accumulation in mouse 3T3L1 cells after 7 days	[PMID: 19022665]
3T3-L1	IC₅₀	0.027 μM Compound: 2, cyclo-[D-allo-Ile1-NMe-L-Ala2-NMe-L-Leu3-L-Leu4-NMe-L-Ala5-NMe-D-Ala6-beta-OH-D-Leu7]	Inhibition of fat-accumulation in mouse 3T3L1 cells Inhibition of fat-accumulation in mouse 3T3L1 cells	[PMID: 19097891]
3T3-L1	IC₅₀	0.28 μM Compound: 1	Toxicity in mouse 3T3L1 cells Toxicity in mouse 3T3L1 cells	[PMID: 18798610]
3T3-L1	IC₅₀	0.28 μM Compound: 1	Cytotoxicity against mouse 3T3L1 cells Cytotoxicity against mouse 3T3L1 cells	[PMID: 19022665]
3T3-L1	IC₅₀	0.28 μM Compound: 2, cyclo-[D-allo-Ile1-NMe-L-Ala2-NMe-L-Leu3-L-Leu4-NMe-L-Ala5-NMe-D-Ala6-beta-OH-D-Leu7]	Cytotoxicity against mouse 3T3L1 cells Cytotoxicity against mouse 3T3L1 cells	[PMID: 19097891]

Chemical Information

CAS. Nr. 148619-41-4
Molecular Weight 737.97
Formel C₃₇H₆₇N₇O₈
Sequence

Cyclo({Ala(N-Me)}-{d-Ala((N-Me)}-{d-Leu((3R)-3-hydroxy)}-{d-Ile}-{Ala(N-Me)}-Leu-Leu)
Sequence Shortening

Cyclo({Ala(N-Me)}-{d-Ala((N-Me)}-{d-Leu((3R)-3-hydroxy)}-{d-Ile}-{Ala(N-Me)}-Leu-Leu)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Large-size fat particle sorting
Large-size fat particle sorting is widely used to isolate cells up to 200 μm in diameter. Single-cell flow sorting will allow greater insight into adipocyte heterogeneity by identifying gene expression, protein composition, and metabolic signatures at the single-cell level.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kenichiro Shimokawa, et al. Structure-based hybridization of the bioactive natural products rhizonin A and ternatin leading to a selective fat-accumulation inhibitor against 3T3-L1 adipocytes. Bioorg Med Chem Lett. 2009 Feb 1;19(3):867-9. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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