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Art. -Nr.: HY-W1139353

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Tetraasterane

Tetraasterane is a hydrophobic tag that promotes the degradation of ALK protein. Tetraasterane can be used for synthesis of ALK degrader 3 (HY-182087).

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CAS. Nr.: 259-77-8
Formel: C₁₂H₁₆
Molecular Weight:160.26

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tetraasterane Chemical Structure

CAS. Nr.: 259-77-8

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Tetraasterane is a hydrophobic tag that promotes the degradation of ALK protein. Tetraasterane can be used for synthesis of ALK degrader 3 (HY-182087)^[1].

In Vitro

Tetraasterane (7 days) conjugated with ALK degrader 3 potently inhibits the proliferation of H3122 cells, with an IC₅₀ of 97.77 nM^[1].
Tetraasterane (0.05-2 μM; 24 h) conjugated with ALK degrader 3 induces concentration-dependent degradation of ALK protein in H3122 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 259-77-8
Molecular Weight 160.26
Formel C₁₂H₁₆
SMILES

C12C(CC3C4C2)C5C1CC4C3C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Chu D, et al. Polyhedral alkanes as hydrophobic tags for dual-functional ALK inhibitor-degrader. Bioorg Chem. 2026 Jun 5;173:109674. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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