Art. -Nr.: HY-118827

Vedaprofen

(Synonyms: Quadrisol; CERM 10202; PM 150)

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Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC₅₀ of 222 μM.

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Reinheit: 98.73%
CAS. Nr.: 71109-09-6
Formel: C₁₉H₂₂O₂
Molecular Weight:282.38

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Vedaprofen Chemical Structure

CAS. Nr.: 71109-09-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition ^[1]. Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC₅₀ of 222 μM^[2].

IC₅₀ & Target

COX-1

Alle COX Isoform-spezifische Produkte anzeigen :

In Vitro

Vedaprofen inhibits horse serum TxB2 and horse exudate PGE2 with IC₅₀s of 9±5 and 630±148 ng/mL, respectively^[1]. Vedaprofen inhibit the E. coli DNA polymerase III β subunit with antibacterial potency^[2]. Vedaprofen shows high E. coli SC binding affinity (K_i=131 μM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetic parameters of vedaprofen in dogs^[3].

Intravenous dose (mg/kg) t_1/2β (h) AUC_{0–48 h} (h·ng/mL) AUC_0–∞ (h·ng/mL)

0.5 16.8±2.2 8612±1135 9518±1223

Oral dose (mg/kg) t_1/2β (h) C_max (ng/mL) t_max (h) AUC_{0–48 h} (h·ng/mL) AUC_0–∞ (h·ng/mL) F_0–∞ (%)

0.5 12.7±2.1 2739±277 0.63±0.14 7090±1311 7650±1348 86±7

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 71109-09-6

Appearance Solid

Molecular Weight 282.38

Formel C₁₉H₂₂O₂

Color White to off-white

SMILES

CC(C1=CC=C(C2CCCCC2)C3=C1C=CC=C3)C(O)=O

Synonyms

Quadrisol; CERM 10202; PM 150

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (177.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5413 mL

17.7066 mL

35.4133 mL

5 mM

0.7083 mL

3.5413 mL

7.0827 mL

10 mM

0.3541 mL

1.7707 mL

3.5413 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Konzentration Konzentration

×
Volumen Volumen

×
Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

×

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

=

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

×

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:

To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO    40% PEG300    5% Tween-80    45% Saline
Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

Protocol 2

Add each solvent one by one: 10% DMSO    90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

Protocol 3

Add each solvent one by one: 10% DMSO    90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg

Animal Weight (Per Animal) Animal Weight (Per Animal)
g

Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL

Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

%
+

+
%
Tween-80 + +

%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact
MedChemExpress (MCE) .

Tel: 609-228-6898
E-mail: [email protected]
Technical Support: [email protected]

Method for preparing in vivo working solution for animal experiments:
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Saline .

Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)

SDS (393 KB)

English - EN (393 KB)

Français - FR (393 KB)

Deutsch - DE (393 KB)

Norwegian - NO (393 KB)

Español - ES (393 KB)

Swedish - SV (393 KB)

Italian - IT (393 KB)

Korean - KR (393 KB)

Portuguese - PT (393 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

Verweise

[1]. P Lees, et al. PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology. J Vet Pharmacol Ther. 2004 Dec;27(6):491-502. [Content Brief]

[2]. Zhou Yin,et al. DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs. Chem Biol. 2014 Apr 24;21(4):481-487. [Content Brief]

[3]. M Hoeijmakers, et al. The pharmacokinetics of Vedaprofen and its enantiomers in dogs after single and multiple dosing. J Vet Pharmacol Ther. 2005 Jun;28(3):305-12. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 3.5413 mL 17.7066 mL 35.4133 mL 88.5332 mL

5 mM 0.7083 mL 3.5413 mL 7.0827 mL 17.7066 mL

10 mM 0.3541 mL 1.7707 mL 3.5413 mL 8.8533 mL

15 mM 0.2361 mL 1.1804 mL 2.3609 mL 5.9022 mL

20 mM 0.1771 mL 0.8853 mL 1.7707 mL 4.4267 mL

25 mM 0.1417 mL 0.7083 mL 1.4165 mL 3.5413 mL

30 mM 0.1180 mL 0.5902 mL 1.1804 mL 2.9511 mL

40 mM 0.0885 mL 0.4427 mL 0.8853 mL 2.2133 mL

50 mM 0.0708 mL 0.3541 mL 0.7083 mL 1.7707 mL

60 mM 0.0590 mL 0.2951 mL 0.5902 mL 1.4756 mL

80 mM 0.0443 mL 0.2213 mL 0.4427 mL 1.1067 mL

100 mM 0.0354 mL 0.1771 mL 0.3541 mL 0.8853 mL

Vedaprofen Related Classifications

HY-118827 Related Classifications

Immunology/Inflammation

COX

Disease Areas

Inflammation or Immune System Disease Musculoskeletal and Skin Disease

Autoimmune Disease Arthritis

Rheumatoid Arthritis

Inflammation/Immunology

Powered by Bioz See more details on Bioz

Keywords

Vedaprofen
71109-09-6
Quadrisol
CERM 10202
PM 150
CERM10202
CERM 10202
CERM-10202
PM150
PM 150
PM-150
COX
COX-1 selective
nonsteroidal
anti-inflammatory drug
NSAID
serum TxB2
exudate PGE2
Escherichia coli
E. coli
sliding clamp
Inhibitor
inhibitor
inhibit

Your Recently Viewed Products

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.5413 mL	17.7066 mL	35.4133 mL	88.5332 mL
5 mM	0.7083 mL	3.5413 mL	7.0827 mL	17.7066 mL
10 mM	0.3541 mL	1.7707 mL	3.5413 mL	8.8533 mL
15 mM	0.2361 mL	1.1804 mL	2.3609 mL	5.9022 mL
20 mM	0.1771 mL	0.8853 mL	1.7707 mL	4.4267 mL
25 mM	0.1417 mL	0.7083 mL	1.4165 mL	3.5413 mL
30 mM	0.1180 mL	0.5902 mL	1.1804 mL	2.9511 mL
40 mM	0.0885 mL	0.4427 mL	0.8853 mL	2.2133 mL
50 mM	0.0708 mL	0.3541 mL	0.7083 mL	1.7707 mL
60 mM	0.0590 mL	0.2951 mL	0.5902 mL	1.4756 mL
80 mM	0.0443 mL	0.2213 mL	0.4427 mL	1.1067 mL
100 mM	0.0354 mL	0.1771 mL	0.3541 mL	0.8853 mL

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Alle COX Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table