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Art. -Nr.: HY-182587

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VU0415248

VU0415248 is a selective muscarinic acetylcholine receptor 1 (M1) inhibitor. VU0415248 inhibits acetylcholine-induced calcium mobilization in cells expressing human and rat M1 muscarinic acetylcholine receptors, with an IC₅₀ of 0.4 and 0.18 μM, respectively. VU0415248 is applicable to the research of Parkinson's disease, movement disorders and fragile X syndrome.

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CAS. Nr.: 1359087-83-4
Formel: C₂₁H₂₃N₅O₃S
Molecular Weight:425.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

VU0415248 Chemical Structure

CAS. Nr.: 1359087-83-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

mAChR1

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Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.18 μM Compound: 13l, VU0415248	Antagonist activity at rat muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by fluorescence assay Antagonist activity at rat muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by fluorescence assay	[PMID: 22197142]

In Vitro

VU0415248 inhibits acetylcholine-induced calcium mobilization in human M1 muscarinic acetylcholine receptor-expressing cells with an IC₅₀ of 0.4 μM^[1].
VU0415248 (30 μM) inhibits acetylcholine-induced calcium mobilization in rat M1 muscarinic acetylcholine receptor-expressing cells with an IC₅₀ of 0.18 μM, and shows very high selectivity over rat and human M2-5 muscarinic acetylcholine receptors (human M2-5 IC₅₀ > 30 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1359087-83-4
Molecular Weight 425.50
Formel C₂₁H₂₃N₅O₃S
SMILES

O=C(CCNS(=O)(C1=CC=CC2=NC=CC=C21)=O)N3CCN(CC3)C4=CC=NC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Melancon BJ, et al. Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012. Bioorg Med Chem Lett. 2012;22(2):1044-1048. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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VU0415248

Alle mAChR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

VU0415248 Related Classifications

HY-182587 Related Classifications