YXX0237
YXX0237 is an orally active anti-hypoxic agent. YXX0237 upregulates mRNA expression of FGF21 and GDF15 via activation of the ISR/ATF4 transcriptional axis. YXX0237 exhibits low cytotoxicity. YXX0237 enhances hypoxic survival in mice. YXX0237 can be used for the research of acute mountain sickness and hypoxia-related diseases.
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- CAS. Nr.: 860445-85-8
- Formel: C12H11N3S
- Molecular Weight:229.30
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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GDF15 |
YXX0237 (10 μM) upregulate FGF21 and GDF15 mRNA in primary liver cells via activation of the ISR/ATF4 transcriptional axis[1].
YXX0237 increases FGF21 and GDF15 mRNA in primary liver cells with EC50s of 11.17 and 1.486 μM[1].
YXX0237 exhibits low cytotoxicity in
HEPG2 and Primary Hepatocytes with CC50s >100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | AUClast | Tmax | T1/2 | Vz/F | CL/F | MRTlast |
|---|---|---|---|---|---|---|---|---|---|
| Mice[1] | 100 mg/kg | p.o. | 3291.70 ng/mL | 23942.32 ng·h/mL | 0.50 h | 2.27 h | 13685.55 mL/kg | 4170.41 mL/mg/kg | 6.97 h |
YXX0237 (25, 50 and 100 mg/kg; p.o.; daily for 3 days) exhibits anti-hypoxia effect in mice[1].
YXX0237 (125, 250 and 500 mg/kg; p.o.; single dose) exhibits low in vivo toxicity in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[1]
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Dosage:50 and 100 mg/kg
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Administration:p.o.; sigle dose
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Result:Upregulated FGF21 and GDF15 expression at both mRNA and protein levels in mouse livers.
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Animal Model:Mice[1]
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Dosage:25, 50 and 100 mg/kg
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Administration:p.o.; daily for 3 days
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Result:Significantly prolonged the survival time of mice under hypoxic conditions.
Exhibited anti-hypoxia effect in a dose-dependent manner.
Chemical Information
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CAS. Nr. 860445-85-8
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Molecular Weight 229.30
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Formel C12H11N3S
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SMILES
CC1=CC=CC(C(NC2=NC=CC=C2)=S)=N1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
YXX0237 Related Classifications
HY-183331 Related Classifications
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