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Boldine (Standard)

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Boldine (Standard) is the analytical standard of Boldine (HY-N6973). This product is intended for research and analytical applications. Boldine is an aporphine alkaloid telomerase (telomerase) inhibitor (IC50 of 0.17 μM for TERT) and a pannexin/connexin hemichannel blocker, with oral activity and blood-brain barrier permeability. Boldine inhibits telomerase activity through direct interaction with the telomerase ribonucleoprotein and non-competitive binding near the TERT active site, and downregulates hTERT mRNA while shifting alternative splicing toward non-functional transcripts. Boldine blocks Panx1, Cx43, Cx26, and Cx30 hemichannels as well as P2X7 receptor-mediated calcium influx. Boldine exhibits antioxidant, anti-inflammatory, antiproliferative, and cytotoxic activities by scavenging ROS, inhibiting NFκB, dephosphorylating SGK1, and reducing TNF-alpha levels. Boldine can be used in research on breast cancer, Alzheimer's disease, glioblastoma, diabetes, and spinal cord injury.

For research use only. We do not sell to patients.

  • Purity : 99.83%
  • CAS No.: 476-70-0
  • Formula: C₁₉H₂₁NO₄
  • Molecular Weight:327.37
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Boldine (Standard) Chemical Structure
    Boldine (Standard) Chemical Structure
CAS No.: 476-70-0
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Boldine (Standard) Chemical Structure
    Boldine (Standard) Chemical Structure
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  • Boldine (Standard)