Daphnetin (Standard)
Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 486-35-1
- Formula: C9H6O4
- Molecular Weight:178.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-N0281
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Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 486-35-1
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Molecular Weight 178.14
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Formula C9H6O4
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SMILES
O=C1C=CC2=CC=C(O)C(O)=C2O1
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Synonyms
7,8-Dihydroxycoumarin (Standard)
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Daphnetin (Standard) Related Classifications
HY-N0281R Related Classifications
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Keywords
- Daphnetin (Standard)
- 486-35-1
- 7,8-Dihydroxycoumarin (Standard)
- Reference Standards
- EGFR
- PKA
- PKC
- Autophagy
- Apoptosis
- AMPK
- Akt
- mTOR
- Reactive Oxygen Species (ROS)
- Caspase
- Bcl-2 Family
- PARP
- Parasite
- Epidermal growth factor receptor
- ErbB-1
- HER1
- Protein kinase A
- Protein kinase C
- AMP-activated protein kinase
- PKB
- Protein kinase B
- Mammalian target of Rapamycin
- poly ADP ribose polymerase
- protein kinase
- apoptosis
- autophagy
- schizontocidal
- inflammation
- A2780 cells
- Inhibitor
- inhibitor
- inhibit